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Lrg1 Gene Detail
Summary
  • Symbol
    Lrg1
  • Name
    leucine-rich alpha-2-glycoprotein 1
  • Synonyms
    1300008B03Rik, 2310031E04Rik, Lrhg
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924155
    NCBI Gene: 76905
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:56426678-56428946 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.17 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924155
 protein coding gene Chr17:56426678-56429001 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023914
 protein coding gene Chr17:57767108-57769374 (-)
A/J MGP_AJ_G0023873
 protein coding gene Chr17:56209827-56212093 (-)
AKR/J MGP_AKRJ_G0023843
 protein coding gene Chr17:56880750-56883016 (-)
BALB/cJ MGP_BALBcJ_G0023875
 protein coding gene Chr17:56033118-56035384 (-)
C3H/HeJ MGP_C3HHeJ_G0023638
 protein coding gene Chr17:57593564-57595830 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024319
 protein coding gene Chr17:60050076-60052342 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021766
 protein coding gene Chr17:52705705-52707971 (-)
CAST/EiJ MGP_CASTEiJ_G0023121
 protein coding gene Chr17:57905431-57907698 (-)
CBA/J MGP_CBAJ_G0023615
 protein coding gene Chr17:62348501-62350767 (-)
DBA/2J MGP_DBA2J_G0023743
 protein coding gene Chr17:54925090-54927356 (-)
FVB/NJ MGP_FVBNJ_G0023709
 protein coding gene Chr17:54445455-54447721 (-)
LP/J MGP_LPJ_G0023823
 protein coding gene Chr17:58471587-58473850 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023736
 protein coding gene Chr17:61902037-61904303 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024364
 protein coding gene Chr17:57257280-57259546 (-)
PWK/PhJ MGP_PWKPhJ_G0022866
 protein coding gene Chr17:54271528-54273796 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022678
 protein coding gene Chr17:54025202-54027463 (-)
WSB/EiJ MGP_WSBEiJ_G0023185
 protein coding gene Chr17:57871302-57873568 (-)



Homology
more
  • Human Ortholog
    LRG1, leucine rich alpha-2-glycoprotein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRG1, leucine rich alpha-2-glycoprotein 1
  • Synonyms
    HMFT1766, LRG
  • Links
    NCBI Gene ID: 116844
    neXtProt AC: NX_P02750
    UniProt: P02750

  • Chr Location
    19p13.3; chr19:4536402-4540036 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit Tgfbr1-dependent increased growth of LCC tumor allografts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    153
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 76905 NCBI Gene Model | MGI Sequence Detail 2269 C57BL/6J ±  kb
transcript NM_029796 RefSeq | MGI Sequence Detail 1372 FVB/N  
polypeptide NP_084072 RefSeq | MGI Sequence Detail 342 FVB/N  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR003591 Leucine-rich repeat, typical subtype
    IPR050328 Multifunctional Developmental and Immune Receptor
  • GlyGen
    Q91XL1 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 153
    cDNA 153

    Microarray probesets 3
Other
Accession IDs
less
MGI:1916869
References
more
  • Summaries
    All 56
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 19
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:357724 Wang X, et al., LRG1 loss effectively restrains glomerular TGF-beta signaling to attenuate diabetic kidney disease. Mol Ther. 2024 Sep 4;32(9):3177-3193
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory