About   Help   FAQ
Arfip2 Gene Detail
Summary
  • Symbol
    Arfip2
  • Name
    ARF interacting protein 2
  • Synonyms
    2310002N04Rik, Arfaptin 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924182
    NCBI Gene: 76932
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:105283410-105289623 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 55.92 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924182
 protein coding gene Chr7:105283408-105289623 (-)
129S1/SvImJ ENSMUSG00200028585
 protein coding gene Chr7:92042602-92047866 (-)
A/J ENSMUSG00195054300
 protein coding gene Chr7:96545177-96550441 (-)
AKR/J ENSMUSG00220048558
 protein coding gene Chr7:89922479-89927742 (-)
BALB/cJ ENSMUSG00180038126
 protein coding gene Chr7:93224713-93229976 (-)
C3H/HeJ ENSMUSG00175050878
 protein coding gene Chr7:93867812-93873075 (-)
C57BL/6NJ ENSMUSG00215050238
 protein coding gene Chr7:93137179-93142441 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030233
 protein coding gene Chr7:108022886-108029074 (-)
CAST/EiJ ENSTCUG00005051064
 protein coding gene Chr7:96544850-96550109 (-)
CBA/J ENSMUSG00210041157
 protein coding gene Chr7:93693308-93698571 (-)
DBA/2J ENSMUSG00185056346
 protein coding gene Chr7:98045714-98050978 (-)
FVB/NJ ENSMUSG00205041261
 protein coding gene Chr7:93677967-93683230 (-)
JF1/MsJ ENSUMUG00000029947
 protein coding gene Chr7:103107098-103112363 (-)
LP/J ENSMUSG00230047861
 protein coding gene Chr7:104147364-104152627 (-)
NOD/ShiLtJ ENSMUSG00190026214
 protein coding gene Chr7:94022563-94027807 (-)
NZO/HlLtJ ENSMUSG00225015197
 protein coding gene Chr7:102339039-102344297 (-)
PWK/PhJ ENSLUMG00010034487
 protein coding gene Chr7:92229659-92234923 (-)
SPRET/EiJ ENSMSPG00010040113
 protein coding gene Chr7:93447534-93453707 (-)
WSB/EiJ ENSIUOG00005049183
 protein coding gene Chr7:94268332-94273584 (-)



Homology
more
  • Human Ortholog
    ARFIP2, ARF interacting protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARFIP2, ARF interacting protein 2
  • Synonyms
    POR1
  • Links
    NCBI Gene ID: 23647
    UniProt: P53365

  • Chr Location
    11p15.4; chr11:6474683-6481479 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit greater diabetic nephropathy following streptozotocin injection, with increased food process effacement, albuminuria, and impaired autophagy but no differences in blood glucose levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    115
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030881 Ensembl Gene Model | MGI Sequence Detail 6214 C57BL/6J ±  kb
    transcript ENSMUST00000131446 Ensembl | MGI Sequence Detail 3275 Not Applicable  
    polypeptide ENSMUSP00000120387 Ensembl | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 115
      cDNA 115

      Microarray probesets 5
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345639 Guo H, et al., ADP-Ribosylation Factor-Interacting Protein 2 Acts as a Novel Regulator of Mitophagy and Autophagy in Podocytes in Diabetic Nephropathy. Antioxidants (Basel). 2024 Jan 8;13(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory