About   Help   FAQ
Arfip2 Gene Detail
Summary
  • Symbol
    Arfip2
  • Name
    ARF interacting protein 2
  • Synonyms
    2310002N04Rik, Arfaptin 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924182
    NCBI Gene: 76932
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:105283410-105289623 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 55.92 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924182
protein coding gene Chr7:105283408-105289623 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032758
protein coding gene Chr7:108897305-108903517 (-)
A/J MGP_AJ_G0032738
protein coding gene Chr7:106044092-106050306 (-)
AKR/J MGP_AKRJ_G0032671
protein coding gene Chr7:108818245-108824459 (-)
BALB/cJ MGP_BALBcJ_G0032744
protein coding gene Chr7:105760617-105766834 (-)
C3H/HeJ MGP_C3HHeJ_G0032453
protein coding gene Chr7:108925902-108932114 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033249
protein coding gene Chr7:113257549-113263762 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030233
protein coding gene Chr7:108022886-108029074 (-)
CAST/EiJ MGP_CASTEiJ_G0031783
protein coding gene Chr7:100752538-100758795 (-)
CBA/J MGP_CBAJ_G0032427
protein coding gene Chr7:117021021-117027235 (-)
DBA/2J MGP_DBA2J_G0032580
protein coding gene Chr7:104313708-104319922 (-)
FVB/NJ MGP_FVBNJ_G0032533
protein coding gene Chr7:104122717-104128930 (-)
LP/J MGP_LPJ_G0032671
protein coding gene Chr7:110299882-110307077 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032565
protein coding gene Chr7:118607441-118613637 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033270
protein coding gene Chr7:107885475-107891684 (-)
PWK/PhJ MGP_PWKPhJ_G0031496
protein coding gene Chr7:97253907-97260122 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031345
protein coding gene Chr7:94995989-95002163 (-)
WSB/EiJ MGP_WSBEiJ_G0031900
protein coding gene Chr7:108528005-108534209 (-)



Homology
more
  • Human Ortholog
    ARFIP2, ARF interacting protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARFIP2, ARF interacting protein 2
  • Synonyms
    POR1
  • Links
    NCBI Gene ID: 23647
    neXtProt AC: NX_P53365
    UniProt: P53365

  • Chr Location
    11p15.4; chr11:6474683-6481479 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit greater diabetic nephropathy following streptozotocin injection, with increased food process effacement, albuminuria, and impaired autophagy but no differences in blood glucose levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030881 Ensembl Gene Model | MGI Sequence Detail 6214 C57BL/6J ±  kb
transcript ENSMUST00000131446 Ensembl | MGI Sequence Detail 3275 Not Applicable  
polypeptide ENSMUSP00000120387 Ensembl | MGI Sequence Detail 341 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 115
    cDNA 115

    Microarray probesets 5
References
more
  • Summaries
    All 46
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 19
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:345639 Guo H, et al., ADP-Ribosylation Factor-Interacting Protein 2 Acts as a Novel Regulator of Mitophagy and Autophagy in Podocytes in Diabetic Nephropathy. Antioxidants (Basel). 2024 Jan 8;13(1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory