Sult2a8 MGI Mouse Gene Detail - MGI:1924221 - sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8

Symbol

Sult2a8
Name

sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8
Synonyms

2810007J24Rik, mL-STL

Feature Type

protein coding gene
IDs

MGI:1924221
NCBI Gene: 76971
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:14144611-14180694 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 8.20 cM
Mapping Data

2 experiments

SNPs within 2kb

781 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924221	protein coding gene	Chr7:14144611-14180705 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031683	protein coding gene	Chr7:11939751-11980504 (-)
A/J	MGP_AJ_G0031657	protein coding gene	Chr7:11660698-11698992 (-)
AKR/J	MGP_AKRJ_G0031580	protein coding gene	Chr7:11993632-12029375 (-)
BALB/cJ	MGP_BALBcJ_G0031662	protein coding gene	Chr7:11857628-11894195 (-)
C3H/HeJ	MGP_C3HHeJ_G0031383	protein coding gene	Chr7:12176454-12212099 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032126	protein coding gene	Chr7:12530359-12568595 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029212	protein coding gene	Chr7:13429986-13467364 (-)
CAST/EiJ	MGP_CASTEiJ_G0030738	protein coding gene	Chr7:9371517-9410288 (-)
CBA/J	MGP_CBAJ_G0031341	protein coding gene	Chr7:12819626-12858396 (-)
DBA/2J	MGP_DBA2J_G0031499	protein coding gene	Chr7:11622409-11657657 (-)
FVB/NJ	MGP_FVBNJ_G0031455	protein coding gene	Chr7:11573805-11610481 (-)
LP/J	MGP_LPJ_G0031585	protein coding gene	Chr7:12002580-12050520 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031490	protein coding gene	Chr7:12995028-13039457 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032156	protein coding gene	Chr7:11748602-11789095 (-)
PWK/PhJ	MGP_PWKPhJ_G0030463	protein coding gene	Chr7:9794287-9832953 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030291	protein coding gene	Chr7:7478867-7520369 (-)
WSB/EiJ	MGP_WSBEiJ_G0030835	protein coding gene	Chr7:11813132-11846989 (-)

Human Ortholog

SULT2A1, sulfotransferase family 2A member 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SULT2A1, sulfotransferase family 2A member 1
Synonyms

DHEAS, DHEA-ST, DHEA-ST8, HST, hSTa, ST2, ST2A1, ST2A3, STD, SULT2A3
Links

HGNC:11458

NCBI Gene ID: 6822

neXtProt AC: NX_Q06520

UniProt: Q06520
Chr Location

19q13.33; chr19:47870467-47886315 (-) GRCh38

MGI Vertebrate Homology

Sult2a8 stringent orthology
1 human;1 mouse;3 zebrafish
HCOP

vertebrate homology predictions: SULT2A1
Gene Tree

Sult2a8

Diseases

1 with human SULT2A1 associations

				Human Disease	Mouse Models
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Genomic Mutations

1 involving Sult2a8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

22
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

852
Tissues

19
cDNA Data

9
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

58
RefSeq

10
UniProt

5
CCDS

CCDS20833.1

Ensembl

ENSMUSG00000030378 (Evidence)
NCBI Gene

76971

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030378	Ensembl Gene Model \| MGI Sequence Detail	36084	C57BL/6J	± kb
transcript	ENSMUST00000168252	Ensembl \| MGI Sequence Detail	2097	Not Applicable
polypeptide	ENSMUSP00000128428	Ensembl \| MGI Sequence Detail	282	Not Applicable

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UniProt

5 Sequences
PDB

7D1X, 7EOV
EC

2.8.2.-, 2.8.2.34
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR000863 Sulfotransferase domain

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All nucleic 11

cDNA 9

Primer pair 2

Microarray probesets 4

Summaries

All 32

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sult2a8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr70673	Chr7:14180576-14180597 (-)	107 bp
Tssr70672	Chr7:14180495-14180512 (-)	190 bp
Tssr70671	Chr7:14180434-14180441 (-)	256 bp
Tssr70670	Chr7:14173563-14173602 (-)	7,111 bp
Tssr70669	Chr7:14172463-14172483 (-)	8,221 bp
Tssr70668	Chr7:14170365-14170382 (-)	10,320 bp
Tssr70667	Chr7:14161776-14161825 (-)	18,893 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24