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Fbxo21 Gene Detail
Summary
  • Symbol
    Fbxo21
  • Name
    F-box protein 21
  • Synonyms
    2810425J22Rik, MGC:28066, mKIAA0875
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924223
    NCBI Gene: 231670
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:118114835-118148263 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 57.73 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    933 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924223
 protein coding gene Chr5:118114795-118148266 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029991
 protein coding gene Chr5:121109680-121145610 (+)
A/J MGP_AJ_G0029955
 protein coding gene Chr5:116166195-116199578 (+)
AKR/J MGP_AKRJ_G0029894
 protein coding gene Chr5:119925424-119958929 (+)
BALB/cJ MGP_BALBcJ_G0029966
 protein coding gene Chr5:117592649-117626278 (+)
C3H/HeJ MGP_C3HHeJ_G0029686
 protein coding gene Chr5:120445941-120480067 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030421
 protein coding gene Chr5:125711891-125747285 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027647
 protein coding gene Chr5:110934903-110968059 (+)
CAST/EiJ MGP_CASTEiJ_G0029095
 protein coding gene Chr5:119468666-119502276 (+)
CBA/J MGP_CBAJ_G0029654
 protein coding gene Chr5:130558995-130595105 (+)
DBA/2J MGP_DBA2J_G0029804
 protein coding gene Chr5:116266865-116300269 (+)
FVB/NJ MGP_FVBNJ_G0029760
 protein coding gene Chr5:115156673-115190772 (+)
LP/J MGP_LPJ_G0029892
 protein coding gene Chr5:121604937-121639583 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029791
 protein coding gene Chr5:134744125-134778843 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030462
 protein coding gene Chr5:119466496-119499816 (+)
PWK/PhJ MGP_PWKPhJ_G0028808
 protein coding gene Chr5:114977025-115011085 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028646
 protein coding gene Chr5:117044828-117078841 (+)
WSB/EiJ MGP_WSBEiJ_G0029170
 protein coding gene Chr5:120039101-120072767 (+)



Homology
more
  • Human Ortholog
    FBXO21, F-box protein 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXO21, F-box protein 21
  • Synonyms
    FBX21
  • Links
    NCBI Gene ID: 23014
    neXtProt AC: NX_O94952
    UniProt: O94952

  • Chr Location
    12q24.22; chr12:117141991-117190470 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in hematopoietic cells exhibit increased susceptibility to 5-FU-induced bone marrow failure and lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    823
  • Tissues
    16
  • cDNA Data
    120
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 231670 NCBI Gene Model | MGI Sequence Detail 33429 C57BL/6J ±  kb
    transcript NM_145564 RefSeq | MGI Sequence Detail 3937 C57BL/6  
    polypeptide Q8VDH1 UniProt | EBI | MGI Sequence Detail 627 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 120
      cDNA 120

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141031
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 14
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory