Atl3 MGI Mouse Gene Detail - MGI:1924270

Symbol

Atl3
Name

atlastin GTPase 3
Synonyms

4633402C03Rik, 5730596K20Rik

Feature Type

protein coding gene
IDs

MGI:1924270
NCBI Gene: 109168
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr19:7471178-7515974 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 5.32 cM
Mapping Data

2 experiments

SNPs within 2kb

996 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924270	protein coding gene	Chr19:7471178-7517039 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024793	protein coding gene	Chr19:4633412-4685694 (+)
A/J	MGP_AJ_G0024760	protein coding gene	Chr19:4272198-4330884 (+)
AKR/J	MGP_AKRJ_G0024733	protein coding gene	Chr19:4407144-4452916 (+)
BALB/cJ	MGP_BALBcJ_G0024760	protein coding gene	Chr19:4386023-4431201 (+)
C3H/HeJ	MGP_C3HHeJ_G0024527	protein coding gene	Chr19:4541426-4589782 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025206	protein coding gene	Chr19:4733516-4784334 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022640	protein coding gene	Chr19:4181466-4224390 (+)
CAST/EiJ	MGP_CASTEiJ_G0024000	protein coding gene	Chr19:4454876-4502539 (+)
CBA/J	MGP_CBAJ_G0024500	protein coding gene	Chr19:4796299-4848785 (+)
DBA/2J	MGP_DBA2J_G0024627	protein coding gene	Chr19:4235498-4281327 (+)
FVB/NJ	MGP_FVBNJ_G0024592	protein coding gene	Chr19:4279025-4323568 (+)
LP/J	MGP_LPJ_G0024713	protein coding gene	Chr19:4486038-4534746 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024622	protein coding gene	Chr19:4699319-4751419 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025254	protein coding gene	Chr19:4575220-4621987 (+)
PWK/PhJ	MGP_PWKPhJ_G0023746	protein coding gene	Chr19:4301915-4347622 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023550	protein coding gene	Chr19:4374190-4418123 (+)
WSB/EiJ	MGP_WSBEiJ_G0024062	protein coding gene	Chr19:4469332-4515881 (+)

Human Ortholog

ATL3, atlastin GTPase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATL3, atlastin GTPase 3
Synonyms

HSN1F
Links

HGNC:24526

NCBI Gene ID: 25923

neXtProt AC: NX_Q6DD88

UniProt: Q6DD88
Chr Location

11q13.1; chr11:63624087-63671974 (-) GRCh38

MGI Vertebrate Homology

Atl3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ATL3
Gene Tree

Atl3

Diseases

1 with human ATL3 associations

				Human Disease	Mouse Models
				hereditary sensory neuropathy type 1F IDs hereditary sensory neuropathy type 1F DOID:0070154 OMIM:615632

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

43
Endonuclease-mediated

1
Gene trapped

41
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

26
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

738
Tissues

3
cDNA Data

91
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atl3

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All Sequences

69
RefSeq

6
UniProt

6
CCDS

CCDS29527.1, CCDS50379.1

Ensembl

ENSMUSG00000024759 (Evidence)
NCBI Gene

109168

			Length	Strain/Species	Flank
genomic	109168	NCBI Gene Model \| MGI Sequence Detail	44797	C57BL/6J	± kb
transcript	NM_001163505	RefSeq \| MGI Sequence Detail	6485	C57BL/6
polypeptide	Q91YH5	UniProt \| EBI \| MGI Sequence Detail	541	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004426 atlastin-3

(term hierarchy)
EC

3.6.5.-
InterPro Domains

IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain

IPR003191 Guanylate-binding protein/Atlastin, C-terminal

IPR036543 Guanylate-binding protein, C-terminal domain superfamily

IPR015894 Guanylate-binding protein, N-terminal

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q91YH5 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 91

cDNA 91

Microarray probesets 10

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MGI:1918076, MGI:2147563, MGI:2147723

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Atl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154754	Chr19:7471385-7471396 (+)	213 bp
Tssr154755	Chr19:7471398-7471433 (+)	238 bp
Tssr154756	Chr19:7471610-7471629 (+)	442 bp
Tssr154757	Chr19:7471792-7471827 (+)	632 bp
Tssr154758	Chr19:7471828-7471839 (+)	656 bp
Tssr154759	Chr19:7471868-7471871 (+)	692 bp
Tssr154760	Chr19:7471887-7471963 (+)	747 bp
Tssr154761	Chr19:7514224-7514235 (+)	43,052 bp
Tssr154762	Chr19:7514237-7514253 (+)	43,067 bp
Tssr154763	Chr19:7514258-7514277 (+)	43,090 bp
Tssr154764	Chr19:7515125-7515141 (+)	43,955 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24