Arid2 MGI Mouse Gene Detail - MGI:1924294 - AT-rich interaction domain 2

Symbol

Arid2
Name

AT-rich interaction domain 2
Synonyms

1700124K17Rik, 4432409D24Rik, zipzap/p200

Feature Type

protein coding gene
IDs

MGI:1924294
NCBI Gene: 77044
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr15:96185399-96302873 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 52.37 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

2339 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924294	protein coding gene	Chr15:96185399-96303344 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022268	protein coding gene	Chr15:97861628-97985959 (+)
A/J	MGP_AJ_G0022227	protein coding gene	Chr15:94034528-94153800 (+)
AKR/J	MGP_AKRJ_G0022202	protein coding gene	Chr15:96854212-96979321 (+)
BALB/cJ	MGP_BALBcJ_G0022233	protein coding gene	Chr15:94232102-94350683 (+)
C3H/HeJ	MGP_C3HHeJ_G0022003	protein coding gene	Chr15:96904208-97031167 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022678	protein coding gene	Chr15:101486040-101616947 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020204	protein coding gene	Chr15:90027041-90151252 (+)
CAST/EiJ	MGP_CASTEiJ_G0021525	protein coding gene	Chr15:97769913-97896185 (+)
CBA/J	MGP_CBAJ_G0021970	protein coding gene	Chr15:104866855-104997621 (+)
DBA/2J	MGP_DBA2J_G0022097	protein coding gene	Chr15:93478400-93598497 (+)
FVB/NJ	MGP_FVBNJ_G0022076	protein coding gene	Chr15:92463460-92583430 (+)
LP/J	MGP_LPJ_G0022168	protein coding gene	Chr15:97983760-98109327 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022096	protein coding gene	Chr15:109078753-109206434 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022693	protein coding gene	Chr15:96981063-97107835 (+)
PWK/PhJ	MGP_PWKPhJ_G0021266	protein coding gene	Chr15:93553787-93673228 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021100	protein coding gene	Chr15:96778324-96904983 (+)
WSB/EiJ	MGP_WSBEiJ_G0021574	protein coding gene	Chr15:97487007-97622557 (+)

Human Ortholog

ARID2, AT-rich interaction domain 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARID2, AT-rich interaction domain 2
Synonyms

BAF200, CSS6, p200, SMARCF3, ZIPZAP
Links

HGNC:18037

NCBI Gene ID: 196528

neXtProt AC: NX_Q68CP9

UniProt: Q68CP9
Chr Location

12q12; chr12:45729706-45908040 (+) GRCh38

MGI Vertebrate Homology

Arid2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARID2
Gene Tree

Arid2

Diseases

3 with human ARID2 associations

				Human Disease	Mouse Models
				Coffin-Siris syndrome 6 IDs Coffin-Siris syndrome 6 DOID:0080297 OMIM:617808
				colorectal cancer IDs colorectal cancer DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

15 phenotypes from 1 allele in 2 genetic backgrounds
40 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

53
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

46
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Arid2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

90 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality between E12.5 and E14.5, congenital heart defects, impaired coronary artery development, subcutaneous edema and hemorrhage.

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All GO Annotations

41
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

852
Tissues

141
cDNA Data

203
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arid2

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All Sequences

59
RefSeq

4
UniProt

6
CCDS

CCDS37185.2

Ensembl

ENSMUSG00000033237 (Evidence)
NCBI Gene

77044

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033237	Ensembl Gene Model \| MGI Sequence Detail	117475	C57BL/6J	± kb
transcript	ENSMUST00000096250	Ensembl \| MGI Sequence Detail	8507	Not Applicable
polypeptide	ENSMUSP00000093969	Ensembl \| MGI Sequence Detail	1828	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004264 AT-rich interactive domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR001606 ARID DNA-binding domain

IPR036431 ARID DNA-binding domain superfamily

IPR016024 Armadillo-type fold

IPR052406 Chromatin Remodeling Complex Component

IPR003150 DNA-binding RFX-type winged-helix domain

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

E9Q7E2 5 sites, 2 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)

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All nucleic 205

cDNA 203

Primer pair 2

Microarray probesets 8

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MGI:1920892

Summaries

All 94

Developmental Gene Expression 15

Diseases 1

Gene Ontology 19

Phenotypes 40
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75

TSS for Arid2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132814	Chr15:96183886-96183905 (+)	-1,503 bp
Tssr132815	Chr15:96184637-96184648 (+)	-756 bp
Tssr132816	Chr15:96184670-96184725 (+)	-701 bp
Tssr132817	Chr15:96184741-96184800 (+)	-628 bp
Tssr132818	Chr15:96184811-96184820 (+)	-583 bp
Tssr132819	Chr15:96185129-96185146 (+)	-261 bp
Tssr132820	Chr15:96185151-96185161 (+)	-243 bp
Tssr132821	Chr15:96185418-96185485 (+)	53 bp
Tssr132822	Chr15:96185647-96185650 (+)	250 bp
Tssr132823	Chr15:96186763-96186774 (+)	1,370 bp
Tssr132824	Chr15:96186786-96186797 (+)	1,393 bp
Tssr132825	Chr15:96240451-96240455 (+)	55,054 bp
Tssr132826	Chr15:96268133-96268144 (+)	82,740 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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