Klhl2 MGI Mouse Gene Detail - MGI:1924363

Symbol

Klhl2
Name

kelch-like 2, Mayven
Synonyms

6030411N21Rik, 8530402H02Rik, ABP-KELCH, Mav

Feature Type

protein coding gene
IDs

MGI:1924363
NCBI Gene: 77113
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:65192709-65302669 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 32.30 cM
Mapping Data

3 experiments

SNPs within 2kb

3414 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924363	protein coding gene	Chr8:65192707-65302821 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033644	protein coding gene	Chr8:64760210-64872346 (-)
A/J	MGP_AJ_G0033626	protein coding gene	Chr8:62028923-62141828 (-)
AKR/J	MGP_AKRJ_G0033551	protein coding gene	Chr8:63796792-63904878 (-)
BALB/cJ	MGP_BALBcJ_G0033622	protein coding gene	Chr8:62312010-62422981 (-)
C3H/HeJ	MGP_C3HHeJ_G0033332	protein coding gene	Chr8:64536681-64647145 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034139	protein coding gene	Chr8:67174476-67291012 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031086	protein coding gene	Chr8:57302447-57408470 (-)
CAST/EiJ	MGP_CASTEiJ_G0032657	protein coding gene	Chr8:63986017-64096607 (-)
CBA/J	MGP_CBAJ_G0033310	protein coding gene	Chr8:69685919-69801650 (-)
DBA/2J	MGP_DBA2J_G0033464	protein coding gene	Chr8:61847640-61957556 (-)
FVB/NJ	MGP_FVBNJ_G0033405	protein coding gene	Chr8:61066522-61174325 (-)
LP/J	MGP_LPJ_G0033552	protein coding gene	Chr8:64798907-64912504 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033449	protein coding gene	Chr8:72237487-72353958 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034157	protein coding gene	Chr8:64092167-64203783 (-)
PWK/PhJ	MGP_PWKPhJ_G0032366	protein coding gene	Chr8:61176340-61383839 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032202	protein coding gene	Chr8:63074643-63191731 (-)
WSB/EiJ	MGP_WSBEiJ_G0032774	protein coding gene	Chr8:64477222-64585403 (-)

Human Ortholog

KLHL2, kelch like family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KLHL2, kelch like family member 2
Synonyms

ABP-KELCH, MAV, MAYVEN
Links

HGNC:6353

NCBI Gene ID: 11275

neXtProt AC: NX_O95198

UniProt: O95198
Chr Location

4q32.3; chr4:165207561-165323156 (+) GRCh38

MGI Vertebrate Homology

Klhl2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KLHL2
Protein SuperFamily

Kelch-like_protein_gigaxonin
Gene Tree

Klhl2

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Phenotype Summary

3 phenotypes from 3 alleles in 3 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

8
Genomic Mutations

1 involving Klhl2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available

Mice homozygous for null mutations are physically normal and do not exhibit hyperkalemia or metabolic acidosis, despite increased WNK4 protein levels in the kidney medulla.

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All GO Annotations

21
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

13
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase klhl2

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All Sequences

55
RefSeq

10
UniProt

3
CCDS

CCDS85544.1

Ensembl

ENSMUSG00000031605 (Evidence)
NCBI Gene

77113

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031605	Ensembl Gene Model \| MGI Sequence Detail	109961	C57BL/6J	± kb
transcript	ENSMUST00000210166	Ensembl \| MGI Sequence Detail	5126	Not Applicable
polypeptide	ENSMUSP00000147262	Ensembl \| MGI Sequence Detail	603	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009381 kelch-like protein 2

(term hierarchy)
InterPro Domains

IPR011705 BTB/Kelch-associated

IPR017096 BTB-kelch protein

IPR000210 BTB/POZ domain

IPR044072 Kelch-like protein 2 , BTB/POZ domain

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta propeller

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 15

cDNA 15

Microarray probesets 3

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MGI:1925485, MGI:2142725

Summaries

All 40

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 11
Earliest

J:47397 Soltysik-Espanola M, et al., Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain. Mol Biol Cell. 1999 Jul;10(7):2361-75
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Klhl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr81435	Chr8:65302657-65302676 (-)	2 bp
Tssr81434	Chr8:65302574-65302633 (-)	65 bp
Tssr81433	Chr8:65302529-65302540 (-)	134 bp
Tssr81432	Chr8:65302499-65302513 (-)	163 bp
Tssr81431	Chr8:65302372-65302395 (-)	285 bp
Tssr81430	Chr8:65290959-65290976 (-)	11,701 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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