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Il33 Gene Detail
Summary
  • Symbol
    Il33
  • Name
    interleukin 33
  • Synonyms
    9230117N10Rik, Il1f11, Il-33, NF-HEV
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924375
    NCBI Gene: 77125
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:29902514-29938118 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 24.56 cM, cytoband C2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924375
 protein coding gene Chr19:29902513-29938118 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025029
 protein coding gene Chr19:28408379-28446643 (+)
A/J MGP_AJ_G0025006
 protein coding gene Chr19:26999073-27036082 (+)
AKR/J MGP_AKRJ_G0024974
 protein coding gene Chr19:27955570-27992194 (+)
BALB/cJ MGP_BALBcJ_G0025005
 protein coding gene Chr19:27032185-27068020 (+)
C3H/HeJ MGP_C3HHeJ_G0024761
 protein coding gene Chr19:27924907-27961658 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025446
 protein coding gene Chr19:29190848-29228368 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022865
 protein coding gene Chr19:26972014-27008717 (+)
CAST/EiJ MGP_CASTEiJ_G0024231
 protein coding gene Chr19:27789572-27829272 (+)
CBA/J MGP_CBAJ_G0024739
 protein coding gene Chr19:30586323-30631223 (+)
DBA/2J MGP_DBA2J_G0024871
 protein coding gene Chr19:26939483-26975524 (+)
FVB/NJ MGP_FVBNJ_G0024833
 protein coding gene Chr19:26781661-26817293 (+)
LP/J MGP_LPJ_G0024956
 protein coding gene Chr19:28405606-28442777 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024860
 protein coding gene Chr19:30480135-30519091 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025501
 protein coding gene Chr19:27972247-28007813 (+)
PWK/PhJ MGP_PWKPhJ_G0023979
 protein coding gene Chr19:26609961-26646520 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023783
 protein coding gene Chr19:27287198-27325537 (+)
WSB/EiJ MGP_WSBEiJ_G0024298
 protein coding gene Chr19:28020069-28058754 (+)



Homology
more
  • Human Ortholog
    IL33, interleukin 33
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL33, interleukin 33
  • Synonyms
    C9orf26, DVS27, IL1F11, NFEHEV, NF-HEV
  • Links
    NCBI Gene ID: 90865
    neXtProt AC: NX_O95760
    UniProt: O95760

  • Chr Location
    9p24.1; chr9:6215149-6257983 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Il33 mouse models; 3 with human IL33 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 6 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    3 images
    233 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations lead to altered Type 2 immunity and increased susceptibility to parasite infection. Homozygotes for a null allele show accelerated ovarian functional decline and early reproductive aging due to impaired migration of ovarian macrophages and failed disposal of atretic follicles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1074
  • Tissues
    57
  • cDNA Data
    40
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024810 Ensembl Gene Model | MGI Sequence Detail 35605 C57BL/6J ±  kb
    transcript ENSMUST00000120388 Ensembl | MGI Sequence Detail 2537 Not Applicable  
    polypeptide ENSMUSP00000113829 Ensembl | MGI Sequence Detail 266 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 40
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 486
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 21
      Phenotypes 233
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:354671 Donahue KL, et al., Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth. Cancer Discov. 2024 Oct 4;14(10):1964-1989
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory