Nxnl1 MGI Mouse Gene Detail - MGI:1924446

Symbol

Nxnl1
Name

nucleoredoxin-like 1
Synonyms

A930031O08Rik, MGC:27601, MGC:28867, RdCVF, Txnl6

Feature Type

protein coding gene
IDs

MGI:1924446
NCBI Gene: 234404
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:72013199-72019245 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.43 cM
Mapping Data

1 experiment

SNPs within 2kb

228 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924446	protein coding gene	Chr8:72013199-72019291 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033754	protein coding gene	Chr8:71973574-71979466 (-)
A/J	MGP_AJ_G0033737	protein coding gene	Chr8:69035574-69041667 (-)
AKR/J	MGP_AKRJ_G0033663	protein coding gene	Chr8:71071154-71077047 (-)
BALB/cJ	MGP_BALBcJ_G0033733	protein coding gene	Chr8:69207514-69213406 (-)
C3H/HeJ	MGP_C3HHeJ_G0033443	protein coding gene	Chr8:71653873-71659765 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034251	protein coding gene	Chr8:74707327-74713421 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031193	protein coding gene	Chr8:63670901-63676673 (-)
CAST/EiJ	MGP_CASTEiJ_G0032768	protein coding gene	Chr8:71115317-71122033 (-)
CBA/J	MGP_CBAJ_G0033421	protein coding gene	Chr8:77360997-77366896 (-)
DBA/2J	MGP_DBA2J_G0033575	protein coding gene	Chr8:68764515-68770407 (-)
FVB/NJ	MGP_FVBNJ_G0033517	protein coding gene	Chr8:67849061-67854953 (-)
LP/J	MGP_LPJ_G0033662	protein coding gene	Chr8:71943245-71949137 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033564	protein coding gene	Chr8:79902477-79908570 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034268	protein coding gene	Chr8:71138305-71144197 (-)
PWK/PhJ	MGP_PWKPhJ_G0032475	protein coding gene	Chr8:68047391-68053595 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032312	protein coding gene	Chr8:70078514-70092432 (-)
WSB/EiJ	MGP_WSBEiJ_G0032884	protein coding gene	Chr8:71484643-71490536 (-)

Human Ortholog

NXNL1, nucleoredoxin like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NXNL1, nucleoredoxin like 1
Synonyms

RDCVF, TXNL6
Links

HGNC:25179

NCBI Gene ID: 115861

neXtProt AC: NX_Q96CM4

UniProt: Q96CM4
Chr Location

19p13.11; chr19:17455425-17460926 (-) GRCh38

MGI Vertebrate Homology

Nxnl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NXNL1
Gene Tree

Nxnl1

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

5
Genomic Mutations

1 involving Nxnl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a kncok-out allele exhibit reduced cone numbers, thin outer nuclear layer, impaired visibility and increased vulnerability to hyperoxia-induced damage.

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All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

9
cDNA Data

15
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nxnl1

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS40385.1

Ensembl

ENSMUSG00000034829 (Evidence)
NCBI Gene

234404

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034829	Ensembl Gene Model \| MGI Sequence Detail	6047	C57BL/6J	± kb
transcript	ENSMUST00000163659	Ensembl \| MGI Sequence Detail	2730	Not Applicable
polypeptide	ENSMUSP00000127094	Ensembl \| MGI Sequence Detail	217	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011540 nucleoredoxin-like protein 1

(term hierarchy)
InterPro Domains

IPR029520 Nucleoredoxin-like protein 1

IPR012336 Thioredoxin-like fold

IPR036249 Thioredoxin-like superfamily

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All nucleic 16

cDNA 16

Microarray probesets 3

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:282558 Collin GB, et al., Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. Cells. 2020 Apr 10;9(4):931

TSS for Nxnl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr81737	Chr8:72019285-72019296 (-)	-46 bp
Tssr81736	Chr8:72019277-72019284 (-)	-36 bp
Tssr81735	Chr8:72019271-72019276 (-)	-29 bp
Tssr81734	Chr8:72019259-72019270 (-)	-20 bp
Tssr81733	Chr8:72019248-72019256 (-)	-7 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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