Sccpdh MGI Mouse Gene Detail - MGI:1924486 - saccharopine dehydrogenase (putative)

Symbol

Sccpdh
Name

saccharopine dehydrogenase (putative)
Synonyms

C330023F11Rik

Feature Type

protein coding gene
IDs

MGI:1924486
NCBI Gene: 109232
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:179495796-179514754 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 83.62 cM
Mapping Data

2 experiments

SNPs within 2kb

614 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924486	protein coding gene	Chr1:179495775-179514754 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016861	protein coding gene	Chr1:186039129-186061122 (+)
A/J	MGP_AJ_G0016840	protein coding gene	Chr1:178545151-178563921 (+)
AKR/J	MGP_AKRJ_G0016806	protein coding gene	Chr1:183859567-183878118 (+)
BALB/cJ	MGP_BALBcJ_G0016798	protein coding gene	Chr1:179172517-179193779 (+)
C3H/HeJ	MGP_C3HHeJ_G0016623	protein coding gene	Chr1:184595375-184619907 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017261	protein coding gene	Chr1:192060261-192099728 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014969	protein coding gene	Chr1:169532950-169551972 (+)
CAST/EiJ	MGP_CASTEiJ_G0016204	protein coding gene	Chr1:183913235-183931678 (+)
CBA/J	MGP_CBAJ_G0016597	protein coding gene	Chr1:199222120-199248285 (+)
DBA/2J	MGP_DBA2J_G0016703	protein coding gene	Chr1:177384406-177405979 (+)
FVB/NJ	MGP_FVBNJ_G0016699	protein coding gene	Chr1:175469381-175488122 (+)
LP/J	MGP_LPJ_G0016777	protein coding gene	Chr1:187313162-187334647 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016730	protein coding gene	Chr1:206353778-206378827 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017298	protein coding gene	Chr1:183592933-183611674 (+)
PWK/PhJ	MGP_PWKPhJ_G0015992	protein coding gene	Chr1:176465428-176484958 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015768	protein coding gene	Chr1:182544140-182563173 (+)
WSB/EiJ	MGP_WSBEiJ_G0016267	protein coding gene	Chr1:183820333-183839858 (+)

Human Ortholog

SCCPDH, saccharopine dehydrogenase (putative)

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCCPDH, saccharopine dehydrogenase (putative)
Synonyms

CGI-49, CGI49, NET11
Links

HGNC:24275

NCBI Gene ID: 51097

neXtProt AC: NX_Q8NBX0

UniProt: Q8NBX0
Chr Location

1q44; chr1:246724409-246768137 (+) GRCh38

MGI Vertebrate Homology

Sccpdh stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: SCCPDH
Gene Tree

Sccpdh

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

2
Endonuclease-mediated

1
Genomic Mutations

2 involving Sccpdh
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

5
cDNA Data

18
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sccpdh

ZFIN sccpdha.1, sccpdhb

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All Sequences

74
RefSeq

7
UniProt

5
CCDS

CCDS15563.1

Ensembl

ENSMUSG00000038936 (Evidence)
NCBI Gene

109232

			Length	Strain/Species	Flank
genomic	109232	NCBI Gene Model \| MGI Sequence Detail	18959	C57BL/6J	± kb
transcript	NR_184455	RefSeq \| MGI Sequence Detail	2001	C57BL/6
polypeptide	Q8R127	UniProt \| EBI \| MGI Sequence Detail	429	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000029749 saccharopine dehydrogenase-like oxidoreductase

(term hierarchy)
EC

1.-.-.-
InterPro Domains

IPR036291 NAD(P)-binding domain superfamily

IPR051276 Saccharopine dehydrogenase-like oxidoreductase

IPR005097 Saccharopine dehydrogenase, NADP binding domain
GlyGen

Q8R127 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 18

cDNA 18

Microarray probesets 6

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MGI:2138579

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sccpdh:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10423	Chr1:179495589-179495599 (+)	-202 bp
Tssr10424	Chr1:179495752-179495763 (+)	-38 bp
Tssr10425	Chr1:179495767-179495833 (+)	4 bp
Tssr10426	Chr1:179495841-179495852 (+)	51 bp
Tssr10427	Chr1:179495863-179495919 (+)	95 bp
Tssr10428	Chr1:179495978-179495985 (+)	186 bp
Tssr10429	Chr1:179504814-179504855 (+)	9,039 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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