Miga1 MGI Mouse Gene Detail - MGI:1924567

Symbol

Miga1
Name

mitoguardin 1
Synonyms

C030011O14Rik, Fam73a, Mita1

Feature Type

protein coding gene
IDs

MGI:1924567
NCBI Gene: 215708
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr3:151979486-152046044 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 77.10 cM
Mapping Data

2 experiments

SNPs within 2kb

1811 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924567	protein coding gene	Chr3:151979096-152046073 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027990	protein coding gene	Chr3:156129662-156194027 (-)
A/J	MGP_AJ_G0027949	protein coding gene	Chr3:150468063-150528322 (-)
AKR/J	MGP_AKRJ_G0027915	protein coding gene	Chr3:154427203-154500375 (-)
BALB/cJ	MGP_BALBcJ_G0027961	protein coding gene	Chr3:150304849-150362787 (-)
C3H/HeJ	MGP_C3HHeJ_G0027691	protein coding gene	Chr3:154872611-154927954 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028404	protein coding gene	Chr3:161273727-161340910 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025742	protein coding gene	Chr3:145303428-145361839 (-)
CAST/EiJ	MGP_CASTEiJ_G0027144	protein coding gene	Chr3:154946286-155004835 (-)
CBA/J	MGP_CBAJ_G0027666	protein coding gene	Chr3:167062529-167130825 (-)
DBA/2J	MGP_DBA2J_G0027806	protein coding gene	Chr3:149574644-149641623 (-)
FVB/NJ	MGP_FVBNJ_G0027773	protein coding gene	Chr3:146950077-147007186 (-)
LP/J	MGP_LPJ_G0027917	protein coding gene	Chr3:157502550-157564570 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027806	protein coding gene	Chr3:175589935-175663582 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028463	protein coding gene	Chr3:154128777-154192263 (-)
PWK/PhJ	MGP_PWKPhJ_G0026867	protein coding gene	Chr3:149459666-149523597 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026695	protein coding gene	Chr3:152279935-152337239 (-)
WSB/EiJ	MGP_WSBEiJ_G0027224	protein coding gene	Chr3:155130959-155192345 (-)

Human Ortholog

MIGA1, mitoguardin 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIGA1, mitoguardin 1
Synonyms

FAM73A
Links

HGNC:24741

NCBI Gene ID: 374986

neXtProt AC: NX_Q8NAN2

UniProt: Q8NAN2
Chr Location

1p31.1; chr1:77779624-77879540 (+) GRCh38

MGI Vertebrate Homology

Miga1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MIGA1
Gene Tree

Miga1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

167
Endonuclease-mediated

5
Gene trapped

159
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

259 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

5
cDNA Data

59
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase miga1

ZFIN miga1

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All Sequences

72
RefSeq

13
UniProt

5
CCDS

CCDS17916.1, CCDS51096.1

Ensembl

ENSMUSG00000054942 (Evidence)
NCBI Gene

215708

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054942	Ensembl Gene Model \| MGI Sequence Detail	66559	C57BL/6J	± kb
transcript	ENSMUST00000073089	Ensembl \| MGI Sequence Detail	4965	Not Applicable
polypeptide	ENSMUSP00000072836	Ensembl \| MGI Sequence Detail	600	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000031471 mitoguardin 1

(term hierarchy)
InterPro Domains

IPR019392 Mitoguardin

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All nucleic 61

Genomic 2

cDNA 59

Microarray probesets 5

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MGI:2139827

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 18
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Miga1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36215	Chr3:152045987-152046053 (-)	24 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24