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Akr1c21 Gene Detail
Summary
  • Symbol
    Akr1c21
  • Name
    aldo-keto reductase family 1, member C21
  • Synonyms
    9430025F20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924587
    NCBI Gene: 77337
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:4624074-4636540 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 2.56 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    438 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924587
 protein coding gene Chr13:4624074-4636542 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020209
 protein coding gene Chr13:1052182-1065267 (+)
A/J MGP_AJ_G0020165
 protein coding gene Chr13:1150741-1166968 (+)
AKR/J MGP_AKRJ_G0020140
 protein coding gene Chr13:1198304-1210770 (+)
BALB/cJ MGP_BALBcJ_G0020148
 protein coding gene Chr13:1160599-1178109 (+)
C3H/HeJ MGP_C3HHeJ_G0019952
 protein coding gene Chr13:1268100-1280566 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020595
 protein coding gene Chr13:1171869-1184335 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0019492
 protein coding gene Chr13:1081129-1101087 (+)
CBA/J MGP_CBAJ_G0019919
 protein coding gene Chr13:1164795-1177261 (+)
DBA/2J MGP_DBA2J_G0020036
 protein coding gene Chr13:1062615-1075672 (+)
FVB/NJ MGP_FVBNJ_G0020021
 protein coding gene Chr13:1019205-1031844 (+)
LP/J MGP_LPJ_G0020110
 protein coding gene Chr13:1162351-1181294 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020057
 protein coding gene Chr13:1280871-1295953 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020623
 protein coding gene Chr13:1143913-1156367 (+)
PWK/PhJ MGP_PWKPhJ_G0019253
 protein coding gene Chr13:1144880-1157486 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019060
 protein coding gene Chr13:1200349-1212719 (+)
WSB/EiJ MGP_WSBEiJ_G0019550
 protein coding gene Chr13:1084117-1096565 (+)



Homology
more
  • Human Ortholog
    AKR1C1, aldo-keto reductase family 1 member C1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKR1C1, aldo-keto reductase family 1 member C1
  • Synonyms
    20-ALPHA-HSD, 2-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB
  • Links
    NCBI Gene ID: 1645
    neXtProt AC: NX_Q04828
    UniProt: Q04828

  • Chr Location
    10p15.1; chr10:4963253-4983283 (+)  GRCh38
  • Human Ortholog
    AKR1C2, aldo-keto reductase family 1 member C2
  • Synonyms
    AKR1C-pseudo, BABP, DD, DD-2, DD2, DD/BABP, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
  • Links
    NCBI Gene ID: 1646
    neXtProt AC: NX_P52895
    UniProt: P52895

  • Chr Location
    10p15.1; chr10:4987775-5018031 (-)  GRCh38
  • Human Ortholog
    AKR1C4, aldo-keto reductase family 1 member C4
  • Synonyms
    3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA
  • Links
    NCBI Gene ID: 1109
    neXtProt AC: NX_P17516
    UniProt: P17516

  • Chr Location
    10p15.1; chr10:5195462-5218949 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human AKR1C2,AKR1C3,AKR1C4 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display increased lung inflammation and injury in response to LPS treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    165
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021207 Ensembl Gene Model | MGI Sequence Detail 12467 C57BL/6J ±  kb
    transcript ENSMUST00000021628 Ensembl | MGI Sequence Detail 1207 Not Applicable  
    polypeptide ENSMUSP00000021628 Ensembl | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 166
      cDNA 166

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145202
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 4
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:322353 Wang X, et al., AKR1C1 alleviates LPSinduced ALI in mice by activating the JAK2/STAT3 signaling pathway. Mol Med Rep. 2021 Dec;24(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory