Lyz3 MGI Mouse Gene Detail - MGI:1924647

Symbol

Lyz3
Name

lysozyme 3
Synonyms

9530003J23Rik

Feature Type

protein coding gene
IDs

MGI:1924647
NCBI Gene: 77397
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr10:117069658-117074586 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 65.28 cM, cytoband D2
Mapping Data

2 experiments

SNPs within 2kb

215 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924647	protein coding gene	Chr10:117068142-117074608 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017755	protein coding gene	Chr10:120094643-120101109 (-)
A/J	MGP_AJ_G0017731	protein coding gene	Chr10:115434476-115440942 (-)
AKR/J	MGP_AKRJ_G0017693	protein coding gene	Chr10:118796119-118802585 (-)
BALB/cJ	MGP_BALBcJ_G0017694	protein coding gene	Chr10:115834480-115840946 (-)
C3H/HeJ	MGP_C3HHeJ_G0017519	protein coding gene	Chr10:119039137-119045603 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018151	protein coding gene	Chr10:124247369-124253835 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015830	protein coding gene	Chr10:110023611-110038710 (-)
CAST/EiJ	MGP_CASTEiJ_G0017081	protein coding gene	Chr10:119343291-119349690 (-)
CBA/J	MGP_CBAJ_G0017488	protein coding gene	Chr10:129143912-129150378 (-)
DBA/2J	MGP_DBA2J_G0017593	protein coding gene	Chr10:114572152-114578618 (-)
FVB/NJ	MGP_FVBNJ_G0017588	protein coding gene	Chr10:113524456-113530922 (-)
LP/J	MGP_LPJ_G0017668	protein coding gene	Chr10:120665016-120671483 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017617	protein coding gene	Chr10:131999335-132005801 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018189	protein coding gene	Chr10:118867243-118873710 (-)
PWK/PhJ	MGP_PWKPhJ_G0016863	protein coding gene	Chr10:114678077-114684875 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016653	protein coding gene	Chr10:117668496-117675135 (-)
WSB/EiJ	MGP_WSBEiJ_G0017141	protein coding gene	Chr10:119060822-119067288 (-)

Human Ortholog

LYZ, lysozyme

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LYZ, lysozyme
Synonyms

AMYLD5, LYZF1, LZM
Links

HGNC:6740

NCBI Gene ID: 4069

neXtProt AC: NX_P61626

UniProt: P61626
Chr Location

12q15; chr12:69348381-69354234 (+) GRCh38

MGI Vertebrate Homology

Lyz3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LYZ
Gene Tree

Lyz3

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Targeted

2
Genomic Mutations

1 involving Lyz3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

8
cDNA Data

7
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

2
UniProt

3
CCDS

CCDS24192.1

Ensembl

ENSMUSG00000020177 (Evidence)
NCBI Gene

77397

			Length	Strain/Species	Flank
genomic	77397	NCBI Gene Model \| MGI Sequence Detail	4929	C57BL/6J	± kb
transcript	NM_029906	RefSeq \| MGI Sequence Detail	1219	C57BL/6
polypeptide	NP_084182	RefSeq \| MGI Sequence Detail	151	C57BL/6

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UniProt

3 Sequences
InterPro Domains

IPR001916 Glycoside hydrolase, family 22

IPR019799 Glycoside hydrolase family 22 domain

IPR000974 Glycoside hydrolase, family 22, lysozyme

IPR023346 Lysozyme-like domain superfamily

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All nucleic 7

cDNA 7

Microarray probesets 2

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MGI:7414204

Summaries

All 26

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 10
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lyz3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99409	Chr10:117074770-117074802 (-)	-200 bp
Tssr99408	Chr10:117074570-117074581 (-)	10 bp
Tssr99407	Chr10:117074552-117074559 (-)	30 bp
Tssr99406	Chr10:117074535-117074546 (-)	45 bp
Tssr99405	Chr10:117074494-117074519 (-)	79 bp
Tssr99404	Chr10:117074478-117074487 (-)	103 bp
Tssr99403	Chr10:117074445-117074464 (-)	131 bp
Tssr99402	Chr10:117070327-117070336 (-)	4,254 bp
Tssr99401	Chr10:117070207-117070215 (-)	4,375 bp
Tssr99400	Chr10:117070106-117070154 (-)	4,456 bp
Tssr99399	Chr10:117069960-117069963 (-)	4,624 bp
Tssr99398	Chr10:117069949-117069956 (-)	4,633 bp
Tssr99397	Chr10:117069926-117069932 (-)	4,657 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24