Spidr MGI Mouse Gene Detail - MGI:1924834 - scaffolding protein involved in DNA repair

Symbol

Spidr
Name

scaffolding protein involved in DNA repair
Synonyms

2310008H04Rik

Feature Type

protein coding gene
IDs

MGI:1924834
NCBI Gene: 224008
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr16:15707088-15964715 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 10.09 cM
Mapping Data

1 experiment

SNPs within 2kb

6284 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924834	protein coding gene	Chr16:15707088-15964715 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022554	protein coding gene	Chr16:12984679-13248755 (-)
A/J	MGP_AJ_G0022515	protein coding gene	Chr16:12290493-12555996 (-)
AKR/J	MGP_AKRJ_G0022492	protein coding gene	Chr16:12801080-13066584 (-)
BALB/cJ	MGP_BALBcJ_G0022520	protein coding gene	Chr16:12450540-12721781 (-)
C3H/HeJ	MGP_C3HHeJ_G0022287	protein coding gene	Chr16:12897888-13165614 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022969	protein coding gene	Chr16:13142224-13414120 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020489	protein coding gene	Chr16:12420170-12641094 (-)
CAST/EiJ	MGP_CASTEiJ_G0021814	protein coding gene	Chr16:12841166-13099387 (-)
CBA/J	MGP_CBAJ_G0022256	protein coding gene	Chr16:13732527-14025780 (-)
DBA/2J	MGP_DBA2J_G0022387	protein coding gene	Chr16:12241854-12500919 (-)
FVB/NJ	MGP_FVBNJ_G0022363	protein coding gene	Chr16:12280906-12537070 (-)
LP/J	MGP_LPJ_G0022455	protein coding gene	Chr16:12772658-13052590 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022385	protein coding gene	Chr16:13416789-13722648 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022982	protein coding gene	Chr16:12744938-13003888 (-)
PWK/PhJ	MGP_PWKPhJ_G0021556	protein coding gene	Chr16:12495638-12735978 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021384	protein coding gene	Chr16:12726471-12994587 (-)
WSB/EiJ	MGP_WSBEiJ_G0021862	protein coding gene	Chr16:12743883-13012723 (-)

Human Ortholog

SPIDR, scaffold protein involved in DNA repair

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPIDR, scaffold protein involved in DNA repair
Synonyms

KIAA0146, ODG9
Links

HGNC:28971

NCBI Gene ID: 23514

neXtProt AC: NX_Q14159

UniProt: Q14159
Chr Location

8q11.21; chr8:47260878-47736306 (+) GRCh38

MGI Vertebrate Homology

Spidr stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SPIDR
Gene Tree

Spidr

Diseases

1 with human SPIDR associations

				Human Disease	Mouse Models
				46 XX gonadal dysgenesis IDs 46 XX gonadal dysgenesis DOID:14450 MESH:D023961 NCI:C120197 OMIM:PS233300 ORDO:243 UMLS_CUI:C0949595

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

59
Endonuclease-mediated

2
Gene trapped

51
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

98 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

26
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

81
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase spidr

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All Sequences

47
RefSeq

8
UniProt

2
CCDS

CCDS27980.1

Ensembl

ENSMUSG00000041974 (Evidence)
NCBI Gene

224008

			Length	Strain/Species	Flank
genomic	224008	NCBI Gene Model \| MGI Sequence Detail	257628	C57BL/6J	± kb
transcript	NM_146068	RefSeq \| MGI Sequence Detail	3303	C57BL/6
polypeptide	Q8BGX7	UniProt \| EBI \| MGI Sequence Detail	933	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000060176 DNA repair-scaffolding protein

(term hierarchy)
InterPro Domains

IPR053054 DNA repair-scaffolding protein

IPR028026 Domain of unknown function DUF4502

IPR028032 Domain of unknown function DUF4503

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All nucleic 82

cDNA 82

Microarray probesets 3

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Spidr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr140116	Chr16:15964635-15964700 (-)	47 bp
Tssr140115	Chr16:15891268-15891314 (-)	73,424 bp
Tssr140114	Chr16:15891256-15891263 (-)	73,455 bp
Tssr140113	Chr16:15784519-15784534 (-)	180,188 bp
Tssr140112	Chr16:15775604-15775607 (-)	189,109 bp
Tssr140111	Chr16:15713661-15713668 (-)	251,050 bp
Tssr140110	Chr16:15713629-15713659 (-)	251,071 bp
Tssr140109	Chr16:15713588-15713596 (-)	251,123 bp
Tssr140108	Chr16:15713571-15713585 (-)	251,137 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24