Adgrf1 MGI Mouse Gene Detail - MGI:1924846 - adhesion G protein-coupled receptor F1

Symbol

Adgrf1
Name

adhesion G protein-coupled receptor F1
Synonyms

5031409J19Rik, Gpr110

Feature Type

protein coding gene
IDs

MGI:1924846
NCBI Gene: 77596
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr17:43581220-43635628 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 19.71 cM
Mapping Data

1 experiment

SNPs within 2kb

2172 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924846	protein coding gene	Chr17:43581174-43636767 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023772	protein coding gene	Chr17:44161931-44197468 (+)
A/J	MGP_AJ_G0023730	protein coding gene	Chr17:43153235-43211656 (+)
AKR/J	MGP_AKRJ_G0023701	protein coding gene	Chr17:43378142-43441139 (+)
BALB/cJ	MGP_BALBcJ_G0023734	protein coding gene	Chr17:43041234-43096794 (+)
C3H/HeJ	MGP_C3HHeJ_G0023498	protein coding gene	Chr17:44086291-44143533 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024177	protein coding gene	Chr17:46109958-46177243 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021627	protein coding gene	Chr17:40004138-40055550 (+)
CAST/EiJ	MGP_CASTEiJ_G0022979	protein coding gene	Chr17:44092308-44154842 (+)
CBA/J	MGP_CBAJ_G0023474	protein coding gene	Chr17:47764010-47834542 (+)
DBA/2J	MGP_DBA2J_G0023600	protein coding gene	Chr17:41964625-42020259 (+)
FVB/NJ	MGP_FVBNJ_G0023567	protein coding gene	Chr17:41522002-41578816 (+)
LP/J	MGP_LPJ_G0023681	protein coding gene	Chr17:44794583-44852866 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023596	protein coding gene	Chr17:47389397-47455706 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024222	protein coding gene	Chr17:43740550-43798586 (+)
PWK/PhJ	MGP_PWKPhJ_G0022724	protein coding gene	Chr17:41208857-41262774 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022539	protein coding gene	Chr17:40597153-40654744 (+)
WSB/EiJ	MGP_WSBEiJ_G0023044	protein coding gene	Chr17:44256520-44311669 (+)

Human Ortholog

ADGRF1, adhesion G protein-coupled receptor F1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADGRF1, adhesion G protein-coupled receptor F1
Synonyms

GPR110, hGPCR36, KPG_012, PGR19
Links

HGNC:18990

NCBI Gene ID: 266977

neXtProt AC: NX_Q5T601

UniProt: Q5T601
Chr Location

6p12.3; chr6:46997708-47042350 (-) GRCh38

MGI Vertebrate Homology

Adgrf1 stringent orthology
1 human;1 mouse;3 zebrafish
HCOP

vertebrate homology predictions: ADGRF1
Gene Tree

Adgrf1

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Phenotype Summary

8 phenotypes from 2 alleles in 3 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a reporter allele exhibit normal viability and fertility.

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All GO Annotations

20
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

18
cDNA Data

5
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adgrf1

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All Sequences

37
RefSeq

7
UniProt

2
CCDS

CCDS28795.1

Ensembl

ENSMUSG00000041293 (Evidence)
NCBI Gene

77596

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041293	Ensembl Gene Model \| MGI Sequence Detail	54409	C57BL/6J	± kb
transcript	ENSMUST00000047399	Ensembl \| MGI Sequence Detail	3853	Not Applicable
polypeptide	ENSMUSP00000049380	Ensembl \| MGI Sequence Detail	908	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030825 adhesion G-protein coupled receptor F1

(term hierarchy)
InterPro Domains

IPR051587 Adhesion G-protein coupled receptor

IPR046338 GAIN domain superfamily

IPR008078 GPCR family 2, Ig-hepta-like receptor

IPR017981 GPCR, family 2-like, 7TM

IPR000832 GPCR, family 2, secretin-like

IPR000203 GPS motif

IPR000082 SEA domain
GlyGen

Q8VEC3 13 sites

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All nucleic 6

cDNA 5

Primer pair 1

Microarray probesets 2

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 17
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:339122 Banerjee S, et al., Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation. J Neuroinflammation. 2023 Aug 14;20(1):187

TSS for Adgrf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144670	Chr17:43581231-43581257 (+)	24 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24