Rbm12b2 MGI Mouse Gene Detail - MGI:1924854 - RNA binding motif protein 12 B2

Symbol

Rbm12b2
Name

RNA binding motif protein 12 B2
Synonyms

C430048L16Rik

Feature Type

protein coding gene
IDs

MGI:1924854
NCBI Gene: 77604
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:12089439-12096243 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 5.58 cM
Mapping Data

2 experiments

SNPs within 2kb

221 from dbSNP Build 142
Strain Annotations

15

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924854	protein coding gene	Chr4:12089370-12105618 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028062	protein coding gene	Chr4:8791721-8799425 (+)
A/J	MGP_AJ_G0028019	protein coding gene	Chr4:8645115-8658162 (+)
AKR/J	MGP_AKRJ_G0027985	protein coding gene	Chr4:8815203-8826340 (+)
BALB/cJ	MGP_BALBcJ_G0028031	protein coding gene	Chr4:8565587-8573795 (+)
C3H/HeJ	MGP_C3HHeJ_G0027760	protein coding gene	Chr4:8912397-9013843 (+)
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0027216	protein coding gene	Chr4:8810642-8821080 (+)
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0027877	protein coding gene	Chr4:8500963-8510337 (+)
FVB/NJ	MGP_FVBNJ_G0027843	protein coding gene	Chr4:8341038-8348234 (+)
LP/J	MGP_LPJ_G0027986	protein coding gene	Chr4:8885104-8890049 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027876	protein coding gene	Chr4:9644120-9664328 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028532	protein coding gene	Chr4:8743982-8756479 (+)
PWK/PhJ	MGP_PWKPhJ_G0026936	protein coding gene	Chr4:8601882-8619369 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026765	protein coding gene	Chr4:8669220-8685011 (+)
WSB/EiJ	MGP_WSBEiJ_G0027293	protein coding gene	Chr4:8819669-8889918 (+)

Human Ortholog

RBM12B, RNA binding motif protein 12B

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBM12B, RNA binding motif protein 12B
Synonyms

MGC:33837
Links

HGNC:32310

NCBI Gene ID: 389677

neXtProt AC: NX_Q8IXT5

UniProt: Q8IXT5
Chr Location

8q22.1; chr8:93728155-93741017 (-) GRCh38

MGI Vertebrate Homology

Rbm12b2 stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: RBM12B
Gene Tree

Rbm12b2

less

References

1 with disease annotations

less

Phenotype Summary

7 phenotype references

All Mutations and Alleles

6
Gene trapped

1
Spontaneous

1
Targeted

1
Transgenic

3
Genomic Mutations

1 involving Rbm12b2
Find Mice (IMSR)

12 strains or lines available

less

All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN rbm12ba, rbm12bb

less

All Sequences

46
RefSeq

10
UniProt

2
CCDS

CCDS17975.1

Ensembl

ENSMUSG00000052137 (Evidence)
NCBI Gene

77604

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052137	Ensembl Gene Model \| MGI Sequence Detail	6805	C57BL/6J	± kb
transcript	ENSMUST00000063839	Ensembl \| MGI Sequence Detail	3327	Not Applicable
polypeptide	ENSMUSP00000066311	Ensembl \| MGI Sequence Detail	834	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000014388 RNA-binding protein 12B-B

(term hierarchy)
InterPro Domains

IPR050666 Epithelial Splicing Regulatory

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR034588 RBM12B, RNA recognition motif 2

IPR035979 RNA-binding domain superfamily

IPR047188 RNA-binding protein 12B, RNA recognition motif 4

IPR000504 RNA recognition motif domain

less

All nucleic 6

cDNA 6

Microarray probesets 3

less

MGI:2140536

Summaries

All 29

Diseases 1

Gene Ontology 2

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:282558 Collin GB, et al., Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. Cells. 2020 Apr 10;9(4):931

TSS for Rbm12b2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36501	Chr4:12089373-12089395 (+)	-55 bp
Tssr36502	Chr4:12095666-12095670 (+)	6,229 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24