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Smpd4 Gene Detail
Summary
  • Symbol
    Smpd4
  • Name
    sphingomyelin phosphodiesterase 4
  • Synonyms
    4122402O22Rik, mKIAA1418, neutral membrane (neutral sphingomyelinase-3)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924876
    NCBI Gene: 77626
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17437218-17462692 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.92 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    503 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924876
 protein coding gene Chr16:17437218-17462694 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022587
 protein coding gene Chr16:14788918-14815508 (+)
A/J MGP_AJ_G0022548
 protein coding gene Chr16:14052403-14078975 (+)
AKR/J MGP_AKRJ_G0022525
 protein coding gene Chr16:14595074-14623961 (+)
BALB/cJ MGP_BALBcJ_G0022551
 protein coding gene Chr16:14207799-14233314 (+)
C3H/HeJ MGP_C3HHeJ_G0022318
 protein coding gene Chr16:14749018-14775392 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023002
 protein coding gene Chr16:15017245-15045318 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020522
 protein coding gene Chr16:14105760-14132547 (+)
CAST/EiJ MGP_CASTEiJ_G0021846
 protein coding gene Chr16:14655081-14681636 (+)
CBA/J MGP_CBAJ_G0022289
 protein coding gene Chr16:15691768-15717686 (+)
DBA/2J MGP_DBA2J_G0022419
 protein coding gene Chr16:13967895-13993386 (+)
FVB/NJ MGP_FVBNJ_G0022395
 protein coding gene Chr16:14008108-14034035 (+)
LP/J MGP_LPJ_G0022486
 protein coding gene Chr16:14541495-14568899 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022416
 protein coding gene Chr16:15382882-15408354 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023013
 protein coding gene Chr16:14545140-14572325 (+)
PWK/PhJ MGP_PWKPhJ_G0021589
 protein coding gene Chr16:14222982-14249624 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021417
 protein coding gene Chr16:14518392-14543877 (+)
WSB/EiJ MGP_WSBEiJ_G0021893
 protein coding gene Chr16:14534885-14560358 (+)



Homology
more
  • Human Ortholog
    SMPD4, sphingomyelin phosphodiesterase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMPD4, sphingomyelin phosphodiesterase 4
  • Synonyms
    NEDMABA, NEDMEBA, NET13, NSMASE-3, NSMASE3, SKNY
  • Links
    NCBI Gene ID: 55627
    neXtProt AC: NX_Q9NXE4
    UniProt: Q9NXE4

  • Chr Location
    2q21.1; chr2:130151392-130182750 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    96
  • cDNA Data
    133
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005899 Ensembl Gene Model | MGI Sequence Detail 25475 C57BL/6J ±  kb
    transcript ENSMUST00000006053 Ensembl | MGI Sequence Detail 4623 Not Applicable  
    polypeptide ENSMUSP00000006053 Ensembl | MGI Sequence Detail 823 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 133
      cDNA 133

      Microarray probesets 7
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory