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Prdm8 Gene Detail
Summary
  • Symbol
    Prdm8
  • Name
    PR domain containing 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924880
    NCBI Gene: 77630
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:98315241-98335313 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 47.77 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    504 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924880
 protein coding gene Chr5:98315057-98336850 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029772
 protein coding gene Chr5:99536857-99544866 (+)
A/J MGP_AJ_G0029738
 protein coding gene Chr5:95846851-95854858 (+)
AKR/J MGP_AKRJ_G0029684
 protein coding gene Chr5:99028156-99036147 (+)
BALB/cJ MGP_BALBcJ_G0029748
 protein coding gene Chr5:96858946-96866937 (+)
C3H/HeJ MGP_C3HHeJ_G0029471
 protein coding gene Chr5:99362669-99370680 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030203
 protein coding gene Chr5:103701336-103709349 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027438
 protein coding gene Chr5:91144469-91152472 (+)
CAST/EiJ MGP_CASTEiJ_G0028882
 protein coding gene Chr5:97974173-97982851 (+)
CBA/J MGP_CBAJ_G0029441
 protein coding gene Chr5:107285247-107295387 (+)
DBA/2J MGP_DBA2J_G0029585
 protein coding gene Chr5:96042408-96050462 (+)
FVB/NJ MGP_FVBNJ_G0029544
 protein coding gene Chr5:94859028-94867019 (+)
LP/J MGP_LPJ_G0029673
 protein coding gene Chr5:100137707-100145848 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029573
 protein coding gene Chr5:112369349-112377344 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030236
 protein coding gene Chr5:98464474-98472465 (+)
PWK/PhJ MGP_PWKPhJ_G0028600
 protein coding gene Chr5:94439205-94447657 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028435
 protein coding gene Chr5:96136187-96144156 (+)
WSB/EiJ MGP_WSBEiJ_G0028960
 protein coding gene Chr5:98792225-98800206 (+)



Homology
more
  • Human Ortholog
    PRDM8, PR/SET domain 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRDM8, PR/SET domain 8
  • Synonyms
    EPM10, KMT8D, PFM5
  • Links
    NCBI Gene ID: 56978
    neXtProt AC: NX_Q9NQV8
    UniProt: Q9NQV8

  • Chr Location
    4q21.21; chr4:80183879-80204329 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRDM8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit premature termination of corticopsinal motor neuron axons, absent corpus callosum and hippocampal commissure, excessive scratching, skin lesions, and contraction of hindpaws resulting a handstand phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    939
  • Tissues
    73
  • cDNA Data
    8
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77630 NCBI Gene Model | MGI Sequence Detail 20073 C57BL/6J ±  kb
    transcript NM_001407995 RefSeq | MGI Sequence Detail 3335 C57BL/6  
    polypeptide Q8BZ97 UniProt | EBI | MGI Sequence Detail 688 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 9
      Primer pair 3
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 14
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory