Pramel13 MGI Mouse Gene Detail - MGI:1924882

Symbol

Pramel13
Name

PRAME like 13
Synonyms

4930569K13Rik, Pramef12

Feature Type

protein coding gene
IDs

MGI:1924882
NCBI Gene: 77632
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:144118244-144135034 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 77.98 cM
Mapping Data

2 experiments

SNPs within 2kb

401 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924882	protein coding gene	Chr4:144118244-144135037 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029090	protein coding gene	Chr4:147751193-147769525 (-)
A/J	MGP_AJ_G0029057	protein coding gene	Chr4:141475155-141491913 (-)
AKR/J	MGP_AKRJ_G0029005	protein coding gene	Chr4:145455344-145472121 (-)
BALB/cJ	MGP_BALBcJ_G0029072	protein coding gene	Chr4:142128277-142145032 (-)
C3H/HeJ	MGP_C3HHeJ_G0028791	protein coding gene	Chr4:145902432-145921644 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029517	protein coding gene	Chr4:152753383-152778787 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026769	protein coding gene	Chr4:134171273-134187622 (-)
CAST/EiJ	MGP_CASTEiJ_G0028207	protein coding gene	Chr4:143977143-143996510 (-)
CBA/J	MGP_CBAJ_G0028755	protein coding gene	Chr4:157512249-157561461 (-)
DBA/2J	MGP_DBA2J_G0028903	protein coding gene	Chr4:141703703-141720691 (-)
FVB/NJ	MGP_FVBNJ_G0028865	protein coding gene	Chr4:140837021-140853766 (-)
LP/J	MGP_LPJ_G0028994	protein coding gene	Chr4:147812973-147830685 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028895	protein coding gene	Chr4:161091330-161110385 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029554	protein coding gene	Chr4:145918417-145938063 (-)
PWK/PhJ	MGP_PWKPhJ_G0027927	protein coding gene	Chr4:138183380-138200910 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027761	protein coding gene	Chr4:141197921-141214436 (-)
WSB/EiJ	MGP_WSBEiJ_G0028286	protein coding gene	Chr4:146182840-146200140 (-)

Human Ortholog

PRAME, PRAME nuclear receptor transcriptional regulator

Vertebrate Orthologs

23

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRAME, PRAME nuclear receptor transcriptional regulator
Synonyms

CT130, MAPE, OIP-4, OIP4
Links

HGNC:9336

NCBI Gene ID: 23532

neXtProt AC: NX_P78395

UniProt: P78395
Chr Location

22q11.22; chr22:22547701-22559361 (-) GRCh38

Human Ortholog

PRAMEF1, PRAME family member 1
Links

HGNC:28840

NCBI Gene ID: 65121

neXtProt AC: NX_O95521

UniProt: O95521
Chr Location

1p36.21; chr1:12791397-12796628 (+) GRCh38

Human Ortholog

PRAMEF10, PRAME family member 10
Links

HGNC:27997

NCBI Gene ID: 343071

neXtProt AC: NX_O60809

UniProt: O60809
Chr Location

1p36.21; chr1:12892896-12898270 (-) GRCh38

Human Ortholog

PRAMEF11, PRAME family member 11
Links

HGNC:14086

NCBI Gene ID: 440560

neXtProt AC: NX_O60813

UniProt: O60813
Chr Location

1p36.21; chr1:12824605-12831410 (-) GRCh38

Human Ortholog

PRAMEF12, PRAME family member 12
Links

HGNC:22125

NCBI Gene ID: 390999

neXtProt AC: NX_O95522

UniProt: O95522
Chr Location

1p36.21; chr1:12773738-12777906 (+) GRCh38

Human Ortholog

PRAMEF13, PRAME family member 13
Links

HGNC:13262

NCBI Gene ID: 400736

neXtProt AC: NX_Q5VWM6

UniProt: Q5VWM6
Chr Location

1p36.21; chr1:13196188-13201409 (-) GRCh38

Human Ortholog

PRAMEF15, PRAME family member 15
Links

HGNC:26764

NCBI Gene ID: 653619

neXtProt AC: NX_P0DUQ1, NX_P0DUQ2

UniProt: P0DUQ1
Chr Location

1p36.21; chr1:13315581-13322598 (+) GRCh38

Human Ortholog

PRAMEF17, PRAME family member 17
Links

HGNC:29485

NCBI Gene ID: 391004

neXtProt AC: NX_Q5VTA0

UniProt: Q5VTA0
Chr Location

1p36.21

Human Ortholog

PRAMEF18, PRAME family member 18
Links

HGNC:30693

NCBI Gene ID: 391003

neXtProt AC: NX_Q5VWM3

UniProt: Q5VWM3
Chr Location

1p36.21; chr1:13222695-13226154 (-) GRCh38

Human Ortholog

PRAMEF19, PRAME family member 19
Links

HGNC:24908

NCBI Gene ID: 645414

neXtProt AC: NX_Q5SWL8

UniProt: Q5SWL8
Chr Location

1p36.21; chr1:13368431-13371947 (-) GRCh38

Human Ortholog

PRAMEF20, PRAME family member 20
Synonyms

PRAMEF21
Links

HGNC:25224

NCBI Gene ID: 645425

neXtProt AC: NX_Q5VT98

UniProt: Q5VT98
Chr Location

1p36.21; chr1:13410450-13421328 (+) GRCh38

Human Ortholog

PRAMEF22, PRAME family member 22
Synonyms

PRAMEF3L
Links

HGNC:34393

NCBI Gene ID: 653606

neXtProt AC: NX_A3QJZ6

UniProt: A3QJZ6
Chr Location

1p36.21; chr1:13005048-13005624 (+) GRCh38

Human Ortholog

PRAMEF25, PRAME family member 25
Links

HGNC:49179

NCBI Gene ID: 441873

neXtProt AC: NX_A6NGN4

UniProt: A6NGN4
Chr Location

1p36.21; chr1:13068677-13077884 (+) GRCh38

Human Ortholog

PRAMEF26, PRAME family member 26
Synonyms

PRAMEF25
Links

HGNC:49178

NCBI Gene ID: 645359

neXtProt AC: NX_A6NGN4

UniProt: H0Y7S4
Chr Location

1p36.21

Human Ortholog

PRAMEF27, PRAME family member 27
Links

HGNC:51234

NCBI Gene ID: 101929983

neXtProt AC: NX_A3QJZ7

UniProt: A3QJZ7
Chr Location

chr1:13049476-13056575 (-) GRCh38

Human Ortholog

PRAMEF33, PRAME family member 33
Synonyms

PRAMEF33P
Links

HGNC:49193

NCBI Gene ID: 645382

neXtProt AC: NX_A0A0G2JMD5

UniProt: A0A0G2JMD5
Chr Location

1p36.21; chr1:13303539-13308907 (+) GRCh38

Human Ortholog

PRAMEF4, PRAME family member 4
Links

HGNC:31971

NCBI Gene ID: 400735

neXtProt AC: NX_O60810

UniProt: O60810
Chr Location

1p36.21; chr1:12879212-12886201 (-) GRCh38

Human Ortholog

PRAMEF5, PRAME family member 5
Synonyms

PRAMEF23, PRAMEF5L
Links

HGNC:27995

NCBI Gene ID: 343068

neXtProt AC: NX_Q5TYX0

UniProt: Q5TYX0
Chr Location

1p36.21; chr1:13254198-13263435 (+) GRCh38

Human Ortholog

PRAMEF6, PRAME family member 6
Links

HGNC:30583

NCBI Gene ID: 440561

neXtProt AC: NX_Q5VXH4

UniProt: Q5VXH4
Chr Location

1p36.21; chr1:12938472-12947580 (-) GRCh38

Human Ortholog

PRAMEF7, PRAME family member 7
Links

HGNC:28415

NCBI Gene ID: 441871

neXtProt AC: NX_Q5VXH5

UniProt: Q5VXH5
Chr Location

1p36.21; chr1:12916610-12920751 (+) GRCh38

Human Ortholog

PRAMEF8, PRAME family member 8
Synonyms

PRAMEF24
Links

HGNC:24074

NCBI Gene ID: 391002

neXtProt AC: NX_Q5VWM4

UniProt: Q5VWM4
Chr Location

1p36.21; chr1:13281304-13285137 (-) GRCh38

Human Ortholog

PRAMEF9, PRAME family member 9
Links

HGNC:27996

NCBI Gene ID: 343070

UniProt: P0DUQ2
Chr Location

1p36.21; chr1:13171848-13179459 (+) GRCh38

MGI Vertebrate Homology

Pramel13 stringent orthology
22 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PRAME, PRAMEF1, PRAMEF10, PRAMEF11, PRAMEF12, PRAMEF13, PRAMEF15, PRAMEF17, PRAMEF18, PRAMEF19, PRAMEF20, PRAMEF22, PRAMEF25, PRAMEF26, PRAMEF27, PRAMEF33, PRAMEF4, PRAMEF5, PRAMEF6, PRAMEF7, PRAMEF8, PRAMEF9
Protein SuperFamily

PRAME
Gene Tree

Pramel13

Diseases

1 with human PRAME associations

				Human Disease	Mouse Models
				myeloid leukemia IDs myeloid leukemia DOID:8692 DOID:8878 DOID:8879 DOID:8910 DOID:9066 DOID:9126 ICD10CM:C92 ICD9CM:205 ICD9CM:205.9 MESH:D007951 NCI:C3172 UMLS_CUI:C0023470

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

12 phenotypes from 3 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

3
Targeted

5
Genomic Mutations

2 involving Pramel13
Incidental Mutations

APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit male infertility, small testes, and azoospermia.

less

All GO Annotations

15
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

61
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

41
RefSeq

8
UniProt

2
CCDS

CCDS18905.1

Ensembl

ENSMUSG00000028591 (Evidence)
NCBI Gene

77632

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028591	Ensembl Gene Model \| MGI Sequence Detail	16791	C57BL/6J	± kb
transcript	ENSMUST00000123854	Ensembl \| MGI Sequence Detail	1596	Not Applicable
polypeptide	ENSMUSP00000119614	Ensembl \| MGI Sequence Detail	463	Not Applicable

less

UniProt

2 Sequences
InterPro Domains

IPR032675 Leucine-rich repeat domain superfamily

IPR026271 PRAME

IPR050694 PRAME domain-containing protein

less

All nucleic 62

cDNA 61

Primer pair 1

Microarray probesets 3

less

MGI:2140472, MGI:2140703, MGI:6430509

Summaries

All 36

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 12
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pramel13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr44455	Chr4:144134967-144135010 (-)	45 bp
Tssr44454	Chr4:144130191-144130210 (-)	4,833 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24