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Trat1 Gene Detail
Summary
  • Symbol
    Trat1
  • Name
    T cell receptor associated transmembrane adaptor 1
  • Synonyms
    C030046M14Rik, Tcrim, Trim
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924897
    NCBI Gene: 77647
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:48551137-48592384 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 30.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1351 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924897
 protein coding gene Chr16:48551137-48630883 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022866
 protein coding gene Chr16:47610033-47645285 (-)
A/J MGP_AJ_G0022831
 protein coding gene Chr16:45513694-45550526 (-)
AKR/J MGP_AKRJ_G0022804
 protein coding gene Chr16:47026055-47066830 (-)
BALB/cJ MGP_BALBcJ_G0022833
 protein coding gene Chr16:45558265-45596499 (-)
C3H/HeJ MGP_C3HHeJ_G0022596
 protein coding gene Chr16:47117971-47157582 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023280
 protein coding gene Chr16:48785038-48830293 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020793
 protein coding gene Chr16:45643509-45678968 (-)
CAST/EiJ MGP_CASTEiJ_G0022122
 protein coding gene Chr16:47368266-47407291 (-)
CBA/J MGP_CBAJ_G0022569
 protein coding gene Chr16:50715426-50749805 (-)
DBA/2J MGP_DBA2J_G0022700
 protein coding gene Chr16:45223829-45266277 (-)
FVB/NJ MGP_FVBNJ_G0022676
 protein coding gene Chr16:45121262-45158436 (-)
LP/J MGP_LPJ_G0022768
 protein coding gene Chr16:47355791-47397487 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022694
 protein coding gene Chr16:50389429-50430703 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023295
 protein coding gene Chr16:47014784-47066321 (-)
PWK/PhJ MGP_PWKPhJ_G0021862
 protein coding gene Chr16:45581891-45618194 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021692
 protein coding gene Chr16:46905829-46948460 (-)
WSB/EiJ MGP_WSBEiJ_G0022167
 protein coding gene Chr16:47068411-47111074 (-)



Homology
more
  • Human Ortholog
    TRAT1, T cell receptor associated transmembrane adaptor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRAT1, T cell receptor associated transmembrane adaptor 1
  • Synonyms
    HSPC062, pp29/30, TCRIM, TRIM
  • Links
    NCBI Gene ID: 50852
    neXtProt AC: NX_Q6PIZ9
    UniProt: Q6PIZ9

  • Chr Location
    3q13.13; chr3:108822770-108855005 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with homozygous disruption of this gene display decreased body weight and a proportional reduction in lymph organ cell numbers; however T and B cell function are normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030775 Ensembl Gene Model | MGI Sequence Detail 41248 C57BL/6J ±  kb
    transcript ENSMUST00000239408 Ensembl | MGI Sequence Detail 684 Not Applicable  
    polypeptide ENSMUSP00000159369 Ensembl | MGI Sequence Detail 197 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016620 T-cell receptor-associated transmembrane adapter 1
      (term hierarchy)
    • InterPro Domains
      IPR020399 T-cell receptor-associated transmembrane adapter 1
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 3
    References
    more
    • Summaries
      All 28
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory