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Defb12 Gene Detail
Summary
  • Symbol
    Defb12
  • Name
    defensin beta 12
  • Synonyms
    9230103N16Rik, mBD-12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924924
    NCBI Gene: 77674
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:19161947-19164850 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    225 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924924
 protein coding gene Chr8:19161947-19164866 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033411
 protein coding gene Chr8:16595261-16596111 (-)
A/J MGP_AJ_G0033392
 protein coding gene Chr8:16028055-16030961 (-)
AKR/J MGP_AKRJ_G0033322
 protein coding gene Chr8:16511878-16514315 (-)
BALB/cJ MGP_BALBcJ_G0033392
 protein coding gene Chr8:16145981-16149414 (-)
C3H/HeJ MGP_C3HHeJ_G0033104
 protein coding gene Chr8:16710467-16713372 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033904
 protein coding gene Chr8:17133182-17136090 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030870
 protein coding gene Chr8:15309154-15312301 (-)
CAST/EiJ MGP_CASTEiJ_G0032427
 protein coding gene Chr8:16544193-16547098 (-)
CBA/J MGP_CBAJ_G0033078
 protein coding gene Chr8:17899282-17902212 (-)
DBA/2J MGP_DBA2J_G0033232
 protein coding gene Chr8:15981752-15984187 (-)
FVB/NJ MGP_FVBNJ_G0033180
 protein coding gene Chr8:15984847-15990036 (-)
LP/J MGP_LPJ_G0033325
 protein coding gene Chr8:16652334-16653184 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033217
 protein coding gene Chr8:18028412-18032099 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033921
 protein coding gene Chr8:16516185-16519093 (-)
PWK/PhJ MGP_PWKPhJ_G0032140
 protein coding gene Chr8:16000893-16003913 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031981
 protein coding gene Chr8:16436966-16440145 (-)
WSB/EiJ MGP_WSBEiJ_G0032543
 protein coding gene Chr8:16613457-16614307 (-)



Homology
more
  • Human Ortholog
    DEFB105A, defensin beta 105A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFB105A, defensin beta 105A
  • Synonyms
    BD-5, DEFB105, DEFB-5
  • Links
    NCBI Gene ID: 245908
    neXtProt AC: NX_Q8NG35
    UniProt: Q8NG35

  • Chr Location
    8p23.1
  • Human Ortholog
    DEFB105B, defensin beta 105B
  • Synonyms
    BD-5, DEFB-5
  • Links
    NCBI Gene ID: 504180
    neXtProt AC: NX_Q8NG35
    UniProt: Q8NG35

  • Chr Location
    8p23.1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 77674 NCBI Gene Model | MGI Sequence Detail 2904 C57BL/6J ±  kb
transcript NM_152802 RefSeq | MGI Sequence Detail 998 C57BL/6  
polypeptide Q8K4N3 UniProt | EBI | MGI Sequence Detail 78 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 1
References
more
  • Summaries
    All 19
    Gene Ontology 3
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory