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Elp4 Gene Detail
Summary
  • Symbol
    Elp4
  • Name
    elongator acetyltransferase complex subunit 4
  • Synonyms
    A330107A17Rik, Paxneb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925016
    NCBI Gene: 77766
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:105531372-105734909 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 55.33 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3690 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925016
 protein coding gene Chr2:105527665-105734909 (-)
129S1/SvImJ ENSMUSG00200007636
 protein coding gene Chr2:102355367-102558940 (-)
A/J ENSMUSG00195028542
 protein coding gene Chr2:102516659-102730737 (-)
AKR/J ENSMUSG00220004991
 protein coding gene Chr2:102262091-102476136 (-)
BALB/cJ ENSMUSG00180029121
 protein coding gene Chr2:102312106-102526179 (-)
C3H/HeJ ENSMUSG00175029648
 protein coding gene Chr2:102611260-102823401 (-)
C57BL/6NJ ENSMUSG00215015692
 protein coding gene Chr2:102418426-102621961 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024038
 protein coding gene Chr2:99167944-99371982 (-)
CAST/EiJ ENSTCUG00005005586
 protein coding gene Chr2:101672358-101873528 (-)
CBA/J ENSMUSG00210036070
 protein coding gene Chr2:102589752-102803808 (-)
DBA/2J ENSMUSG00185038965
 protein coding gene Chr2:102308682-102522752 (-)
FVB/NJ no annotation
JF1/MsJ ENSUMUG00000003217
 protein coding gene Chr2:102020889-102232977 (-)
LP/J ENSMUSG00230004167
 protein coding gene Chr2:104057958-104272017 (-)
NOD/ShiLtJ ENSMUSG00190014814
 protein coding gene Chr2:102436645-102640239 (-)
NZO/HlLtJ ENSMUSG00225008306
 protein coding gene Chr2:111966859-112170433 (-)
PWK/PhJ ENSLUMG00010022877
 protein coding gene Chr2:102023663-102226518 (-)
SPRET/EiJ ENSMSPG00010035140
 protein coding gene Chr2:104062276-104298824 (-)
WSB/EiJ ENSIUOG00005031100
 protein coding gene Chr2:102111288-102314914 (-)



Homology
more
  • Human Ortholog
    ELP4, elongator acetyltransferase complex subunit 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELP4, elongator acetyltransferase complex subunit 4
  • Synonyms
    AN, AN2, C11orf19, dJ68P15A.1, hELP4, PAX6NEB, PAXNEB
  • Links
    NCBI Gene ID: 26610
    UniProt: Q96EB1

  • Chr Location
    11p13; chr11:31509755-31790324 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ELP4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    620
  • Tissues
    12
  • cDNA Data
    16
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027167 Ensembl Gene Model | MGI Sequence Detail 203538 C57BL/6J ±  kb
    transcript ENSMUST00000122965 Ensembl | MGI Sequence Detail 3048 Not Applicable  
    polypeptide ENSMUSP00000116575 Ensembl | MGI Sequence Detail 422 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 2
      Antibodies 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:360776 Di Michele M, et al., E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development. Nat Commun. 2025 Jan 2;16(1):67
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory