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Rrn3 Gene Detail
Summary
  • Symbol
    Rrn3
  • Name
    RRN3 RNA polymerase I transcription factor homolog (yeast)
  • Synonyms
    E130302O19Rik, TIF-1A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925255
    NCBI Gene: 106298
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:13598572-13632703 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 9.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    868 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925255
 protein coding gene Chr16:13598563-13632705 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022535
 protein coding gene Chr16:10778780-10814108 (+)
A/J MGP_AJ_G0022497
 protein coding gene Chr16:10188666-10223547 (+)
AKR/J MGP_AKRJ_G0022473
 protein coding gene Chr16:10633683-10668879 (+)
BALB/cJ MGP_BALBcJ_G0022501
 protein coding gene Chr16:10352248-10387504 (+)
C3H/HeJ MGP_C3HHeJ_G0022268
 protein coding gene Chr16:10724326-10760504 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022950
 protein coding gene Chr16:10941843-10978517 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020470
 protein coding gene Chr16:10275599-10313406 (+)
CAST/EiJ MGP_CASTEiJ_G0021795
 protein coding gene Chr16:10736474-10778530 (+)
CBA/J MGP_CBAJ_G0022237
 protein coding gene Chr16:11464230-11510516 (+)
DBA/2J MGP_DBA2J_G0022368
 protein coding gene Chr16:10177689-10211843 (+)
FVB/NJ MGP_FVBNJ_G0022344
 protein coding gene Chr16:10164695-10199449 (+)
LP/J MGP_LPJ_G0022436
 protein coding gene Chr16:10688067-10722411 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022366
 protein coding gene Chr16:11092534-11132428 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022963
 protein coding gene Chr16:10604462-10644056 (+)
PWK/PhJ MGP_PWKPhJ_G0021537
 protein coding gene Chr16:10442681-10477947 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021365
 protein coding gene Chr16:10593296-10631835 (+)
WSB/EiJ MGP_WSBEiJ_G0021843
 protein coding gene Chr16:10622912-10659155 (+)



Homology
more
  • Human Ortholog
    RRN3, RRN3 homolog, RNA polymerase I transcription factor
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RRN3, RRN3 homolog, RNA polymerase I transcription factor
  • Synonyms
    A-270G1.2, TIFIA
  • Links
    NCBI Gene ID: 54700
    neXtProt AC: NX_Q9NYV6
    UniProt: Q9NYV6

  • Chr Location
    16p13.11; chr16:15060022-15094335 (-)  GRCh38
  • Human Ortholog
    RRN3P1, RRN3 pseudogene 1
  • Links
    NCBI Gene ID: 730092
    UniProt: Q2M238

  • Chr Location
    16p12.2; chr16:21796630-21820384 (-)  GRCh38
  • Human Ortholog
    RRN3P2, RRN3 pseudogene 2
  • Links
    NCBI Gene ID: 653390
    UniProt: A6NIE6

  • Chr Location
    16p11.2; chr16:29074842-29116718 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rrn3 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during organogenesis, failure to undergo embryonic turning, delayed embryonic development, markedly reduced embryo size, and increased apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    15
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022682 Ensembl Gene Model | MGI Sequence Detail 34132 C57BL/6J ±  kb
    transcript ENSMUST00000023363 Ensembl | MGI Sequence Detail 3582 Not Applicable  
    polypeptide ENSMUSP00000023363 Ensembl | MGI Sequence Detail 656 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000014308 RNA polymerase I-specific transcription initiation factor RRN3
      (term hierarchy)
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR007991 RNA polymerase I specific transcription initiation factor RRN3
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146525, MGI:2146736
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:15147 Schnapp A, et al., Function of the growth-regulated transcription initiation factor TIF-IA in initiation complex formation at the murine ribosomal gene promoter. Mol Cell Biol. 1993 Nov;13(11):6723-32
    • Latest
      J:348364 Radlicka-Borysewska A, et al., Non-motor symptoms associated with progressive loss of dopaminergic neurons in a mouse model of Parkinson's disease. Front Neurosci. 2024;18:1375265
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory