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Flicr Gene Detail
Summary
  • Symbol
    Flicr
  • Name
    Foxp3 regulating long intergenic noncoding RNA
  • Synonyms
    4930524L23Rik, Ppp1r3fos
  • Feature Type
    lncRNA gene
  • IDs
    MGI:1925435
    NCBI Gene: 78185
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7439839-7447255 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 3.41 cM, cytoband A1.1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    157 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925435
 lncRNA gene ChrX:7439839-7447266 (+)
129S1/SvImJ MGP_129S1SvImJ_G0004714
 antisense lncRNA gene ChrX:2183683-2191103 (+)
A/J MGP_AJ_G0004692
 antisense lncRNA gene ChrX:2145080-2153678 (+)
AKR/J MGP_AKRJ_G0004675
 antisense lncRNA gene ChrX:2248603-2256013 (+)
BALB/cJ MGP_BALBcJ_G0004676
 antisense lncRNA gene ChrX:2165405-2172865 (+)
C3H/HeJ MGP_C3HHeJ_G0004624
 antisense lncRNA gene ChrX:2218464-2227081 (+)
C57BL/6NJ MGP_C57BL6NJ_G0004825
 antisense lncRNA gene ChrX:2260650-2269509 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0004266
 antisense lncRNA gene ChrX:1714970-1722336 (+)
CAST/EiJ MGP_CASTEiJ_G0004581
 antisense lncRNA gene ChrX:2120771-2128192 (+)
CBA/J MGP_CBAJ_G0004619
 antisense lncRNA gene ChrX:2374434-2381866 (+)
DBA/2J MGP_DBA2J_G0004634
 antisense lncRNA gene ChrX:2167132-2174546 (+)
FVB/NJ MGP_FVBNJ_G0004652
 antisense lncRNA gene ChrX:2131541-2139276 (+)
LP/J MGP_LPJ_G0004716
 antisense lncRNA gene ChrX:2187548-2194965 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0004638
 antisense lncRNA gene ChrX:2340392-2347871 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0004825
 antisense lncRNA gene ChrX:2167428-2174839 (+)
PWK/PhJ MGP_PWKPhJ_G0004533
 antisense lncRNA gene ChrX:2099337-2106757 (+)
SPRET/EiJ MGP_SPRETEiJ_G0004470
 antisense lncRNA gene ChrX:2139125-2146531 (+)
WSB/EiJ MGP_WSBEiJ_G0004624
 antisense lncRNA gene ChrX:2171013-2178427 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout mice of this negative regulator of Foxp3 show decreased susceptibility to autoimmune diabetes and reduced severity of insulitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
less
  • All Sequences
    32
  • RefSeq
    1
  • UniProt
    2
Representative SequencesLengthStrain/SpeciesFlank
genomic 78185 NCBI Gene Model | MGI Sequence Detail 7417 C57BL/6J ±  kb
transcript NR_029473 RefSeq | MGI Sequence Detail 3456 C57BL/6  
polypeptide Q8BNV6 UniProt | EBI | MGI Sequence Detail 130 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 1
Other
Accession IDs
less
MGI:5901917
References
more
  • Summaries
    All 14
    Gene Ontology 1
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:241346 Zemmour D, et al., Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3472-E3480
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory