Gng13 MGI Mouse Gene Detail - MGI:1925616 - guanine nucleotide binding protein (G protein), gamma 13

Symbol

Gng13
Name

guanine nucleotide binding protein (G protein), gamma 13
Synonyms

Ggamma13

Feature Type

protein coding gene
IDs

MGI:1925616
NCBI Gene: 64337
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr17:25936146-25938076 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 12.82 cM, cytoband A3.3
Mapping Data

2 experiments

SNPs within 2kb

109 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925616	protein coding gene	Chr17:25936145-25938380 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023360	protein coding gene	Chr17:24808391-24810613 (+)
A/J	MGP_AJ_G0023319	protein coding gene	Chr17:24087727-24089962 (+)
AKR/J	MGP_AKRJ_G0023285	protein coding gene	Chr17:24193291-24195513 (+)
BALB/cJ	MGP_BALBcJ_G0023324	protein coding gene	Chr17:24312422-24314644 (+)
C3H/HeJ	MGP_C3HHeJ_G0023084	protein coding gene	Chr17:24575636-24577871 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023766	protein coding gene	Chr17:25858869-25861104 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021242	protein coding gene	Chr17:21549906-21552160 (+)
CAST/EiJ	MGP_CASTEiJ_G0022586	protein coding gene	Chr17:24454253-24456484 (+)
CBA/J	MGP_CBAJ_G0023059	protein coding gene	Chr17:26766259-26768494 (+)
DBA/2J	MGP_DBA2J_G0023189	protein coding gene	Chr17:23689340-23691575 (+)
FVB/NJ	MGP_FVBNJ_G0023159	protein coding gene	Chr17:23426226-23428461 (+)
LP/J	MGP_LPJ_G0023266	protein coding gene	Chr17:25103422-25105644 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023178	protein coding gene	Chr17:26382955-26385190 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023806	protein coding gene	Chr17:24501824-24504059 (+)
PWK/PhJ	MGP_PWKPhJ_G0022335	protein coding gene	Chr17:22451219-22453451 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022153	protein coding gene	Chr17:22578187-22580419 (+)
WSB/EiJ	MGP_WSBEiJ_G0022649	protein coding gene	Chr17:24563125-24565360 (+)

Human Ortholog

GNG13, G protein subunit gamma 13

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GNG13, G protein subunit gamma 13
Synonyms

G(gamma)13, h2-35, HG3J
Links

HGNC:14131

NCBI Gene ID: 51764

neXtProt AC: NX_Q9P2W3

UniProt: Q9P2W3
Chr Location

16p13.3; chr16:798041-800734 (-) GRCh38

MGI Vertebrate Homology

Gng13 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GNG13
Gene Tree

Gng13

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Phenotype Summary

14 phenotypes from 3 alleles in 3 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Gene trapped

2
Radiation induced

2
Targeted

5
Genomic Mutations

2 involving Gng13
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele are infertile and display a progressive reduction in scotopic but not photopic ERG b-waves.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

764
Tissues

31
cDNA Data

9
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gng13

ZFIN gng13a, gng13b

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All Sequences

40
RefSeq

4
UniProt

1
CCDS

CCDS37503.1

Ensembl

ENSMUSG00000025739 (Evidence)
NCBI Gene

64337

			Length	Strain/Species	Flank
genomic	64337	NCBI Gene Model \| MGI Sequence Detail	1931	C57BL/6J	± kb
transcript	NM_022422	RefSeq \| MGI Sequence Detail	438	C57BL/6
polypeptide	Q9JMF3	UniProt \| EBI \| MGI Sequence Detail	67	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008106 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

(term hierarchy)
InterPro Domains

IPR015898 G-protein gamma-like domain

IPR036284 G-protein gamma-like domain superfamily

IPR039227 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

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All nucleic 13

cDNA 11

Primer pair 2

Microarray probesets 4

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MGI:1927604

Summaries

All 56

Developmental Gene Expression 10

Gene Ontology 7

Phenotypes 17
Earliest

J:68225 Huang L, et al., Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. Nat Neurosci. 1999 Dec;2(12):1055-62
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gng13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143169	Chr17:25936162-25936187 (+)	29 bp
Tssr143170	Chr17:25936188-25936210 (+)	53 bp
Tssr143171	Chr17:25936463-25936525 (+)	348 bp
Tssr143172	Chr17:25937199-25937205 (+)	1,056 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24