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Mvp Gene Detail
Summary
  • Symbol
    Mvp
  • Name
    major vault protein
  • Synonyms
    2310009M24Rik, LRP, VAULT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925638
    NCBI Gene: 78388
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126586036-126613729 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.26 cM, cytoband F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    742 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925638
 protein coding gene Chr7:126586032-126613793 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033012
 protein coding gene Chr7:131298539-131328021 (-)
A/J MGP_AJ_G0032995
 protein coding gene Chr7:127814489-127842218 (-)
AKR/J MGP_AKRJ_G0032927
 protein coding gene Chr7:131050171-131077901 (-)
BALB/cJ MGP_BALBcJ_G0033000
 protein coding gene Chr7:127477436-127505640 (-)
C3H/HeJ MGP_C3HHeJ_G0032710
 protein coding gene Chr7:130990166-131019522 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033506
 protein coding gene Chr7:136402002-136433129 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030478
 protein coding gene Chr7:129025218-129054661 (-)
CAST/EiJ MGP_CASTEiJ_G0032039
 protein coding gene Chr7:122778370-122808401 (-)
CBA/J MGP_CBAJ_G0032683
 protein coding gene Chr7:140990248-141021039 (-)
DBA/2J MGP_DBA2J_G0032835
 protein coding gene Chr7:125788533-125816272 (-)
FVB/NJ MGP_FVBNJ_G0032788
 protein coding gene Chr7:125639010-125667597 (-)
LP/J MGP_LPJ_G0032929
 protein coding gene Chr7:132763452-132797530 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032820
 protein coding gene Chr7:142156256-142186932 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033525
 protein coding gene Chr7:130064485-130094520 (-)
PWK/PhJ MGP_PWKPhJ_G0031746
 protein coding gene Chr7:118784425-118812915 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031592
 protein coding gene Chr7:116903459-116935288 (-)
WSB/EiJ MGP_WSBEiJ_G0032151
 protein coding gene Chr7:131041639-131070159 (-)



Homology
more
  • Human Ortholog
    MVP, major vault protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MVP, major vault protein
  • Synonyms
    LRP, VAULT1
  • Links
    NCBI Gene ID: 9961
    neXtProt AC: NX_Q14764
    UniProt: Q14764

  • Chr Location
    16p11.2; chr16:29820394-29848039 (+)  GRCh38
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    49 phenotype references
Targeted disruption of this gene does not induce hypersensitivity to various cytostatic agents. Homozygotes are viable, healthy and phenotypically normal and exhibit unimpaired dendritic cell maturation and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    793
  • Tissues
    11
  • cDNA Data
    119
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 78388 NCBI Gene Model | MGI Sequence Detail 27694 C57BL/6J ±  kb
transcript NM_080638 RefSeq | MGI Sequence Detail 2765 C57BL/6  
polypeptide Q9EQK5 UniProt | EBI | MGI Sequence Detail 861 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 119
    cDNA 119

    Microarray probesets 5
References
more
  • Summaries
    All 86
    Developmental Gene Expression 3
    Diseases 3
    Gene Ontology 6
    Phenotypes 49
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:349484 Henis M, et al., The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation. Sci Adv. 2024 Apr 12;10(15):eadf7001
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory