Helz MGI Mouse Gene Detail - MGI:1925705 - helicase with zinc finger domain

Symbol

Helz
Name

helicase with zinc finger domain
Synonyms

3110078M01Rik, 9430093I07Rik, 9630002H22Rik

Feature Type

protein coding gene
IDs

MGI:1925705
NCBI Gene: 78455
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:107438756-107584652 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 70.29 cM
Mapping Data

3 experiments

SNPs within 2kb

3651 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925705	protein coding gene	Chr11:107437789-107584652 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019321	protein coding gene	Chr11:110962608-111113841 (+)
A/J	MGP_AJ_G0019289	protein coding gene	Chr11:106198030-106346056 (+)
AKR/J	MGP_AKRJ_G0019258	protein coding gene	Chr11:109371617-109525554 (+)
BALB/cJ	MGP_BALBcJ_G0019263	protein coding gene	Chr11:106620072-106766478 (+)
C3H/HeJ	MGP_C3HHeJ_G0019072	protein coding gene	Chr11:109681234-109839315 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019713	protein coding gene	Chr11:114381699-114543828 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017337	protein coding gene	Chr11:103460743-103607563 (+)
CAST/EiJ	MGP_CASTEiJ_G0018625	protein coding gene	Chr11:110785411-110938592 (+)
CBA/J	MGP_CBAJ_G0019041	protein coding gene	Chr11:119112776-119268082 (+)
DBA/2J	MGP_DBA2J_G0019153	protein coding gene	Chr11:105677456-105823439 (+)
FVB/NJ	MGP_FVBNJ_G0019144	protein coding gene	Chr11:105171061-105330726 (+)
LP/J	MGP_LPJ_G0019223	protein coding gene	Chr11:111401722-111558944 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019174	protein coding gene	Chr11:118322004-118491449 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019750	protein coding gene	Chr11:109917444-110077435 (+)
PWK/PhJ	MGP_PWKPhJ_G0018390	protein coding gene	Chr11:106811777-106967632 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018181	protein coding gene	Chr11:109682471-109841694 (+)
WSB/EiJ	MGP_WSBEiJ_G0018676	protein coding gene	Chr11:109870777-110026457 (+)

Human Ortholog

HELZ, helicase with zinc finger

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HELZ, helicase with zinc finger
Synonyms

DHRC, DRHC, HUMORF5
Links

HGNC:16878

NCBI Gene ID: 9931

neXtProt AC: NX_P42694

UniProt: P42694
Chr Location

17q24.2; chr17:67070444-67245989 (-) GRCh38

MGI Vertebrate Homology

Helz stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HELZ
Gene Tree

Helz

less

Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

108
Endonuclease-mediated

2
Gene trapped

105
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

122 strains or lines available

Mice homozygous for a gene-trapped allele are viable, fertile and phenotypically normal with no apparent skeletal defects.

less

All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase helz

ZFIN helz

less

All Sequences

70
RefSeq

16
UniProt

3
CCDS

CCDS25569.1, CCDS88275.1

Ensembl

ENSMUSG00000020721 (Evidence)
NCBI Gene

78455

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020721	Ensembl Gene Model \| MGI Sequence Detail	145897	C57BL/6J	± kb
transcript	ENSMUST00000075012	Ensembl \| MGI Sequence Detail	6218	Not Applicable
polypeptide	ENSMUSP00000074533	Ensembl \| MGI Sequence Detail	1965	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000030634 probable helicase with zinc finger domain

(term hierarchy)
EC

3.6.4.-
InterPro Domains

IPR009818 Ataxin-2, C-terminal

IPR041677 DNA2/NAM7 helicase, helicase domain

IPR041679 DNA2/NAM7 helicase-like, C-terminal

IPR045055 DNA2/NAM7-like helicase

IPR049569 Helicase with zinc finger, DEAD-box 1

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR047187 Upf1-like, C-terminal helicase domain

IPR014016 UvrD-like helicase, ATP-binding domain

IPR000571 Zinc finger, CCCH-type

IPR036855 Zinc finger, CCCH-type superfamily
GlyGen

Q6DFV5 2 sites, 1 O-linked glycan (2 sites)

less

All nucleic 13

cDNA 13

Microarray probesets 10

less

MGI:1920477, MGI:1924751, MGI:2144311

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 12
Earliest

J:57448 Wagner DS, et al., Identification of a differentially expressed RNA helicase by gene trapping. Biochem Biophys Res Commun. 1999 Sep 7;262(3):677-84
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Helz:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105590	Chr11:107437672-107437716 (+)	-1,062 bp
Tssr105591	Chr11:107437728-107437749 (+)	-1,017 bp
Tssr105592	Chr11:107437758-107437802 (+)	-976 bp
Tssr105593	Chr11:107438751-107438785 (+)	12 bp
Tssr105594	Chr11:107439661-107439667 (+)	908 bp
Tssr105595	Chr11:107484649-107484652 (+)	45,895 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24