Arhgap10 MGI Mouse Gene Detail - MGI:1925764 - Rho GTPase activating protein 10

Symbol

Arhgap10
Name

Rho GTPase activating protein 10
Synonyms

A930033B01Rik, PSGAP-m, PSGAP-s

Feature Type

protein coding gene
IDs

MGI:1925764
NCBI Gene: 78514
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr8:77976995-78244582 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 36.60 cM, cytoband C2
Mapping Data

2 experiments

SNPs within 2kb

8717 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925764	protein coding gene	Chr8:77976995-78244628 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033800	protein coding gene	Chr8:77823484-78101975 (-)
A/J	MGP_AJ_G0033782	protein coding gene	Chr8:74711154-74973426 (-)
AKR/J	MGP_AKRJ_G0033709	protein coding gene	Chr8:76943137-77210866 (-)
BALB/cJ	MGP_BALBcJ_G0033776	protein coding gene	Chr8:74820244-75086336 (-)
C3H/HeJ	MGP_C3HHeJ_G0033485	protein coding gene	Chr8:77560027-77838325 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034296	protein coding gene	Chr8:80807935-81097787 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031237	protein coding gene	Chr8:68813249-69069311 (-)
CAST/EiJ	MGP_CASTEiJ_G0032815	protein coding gene	Chr8:76878683-77156942 (-)
CBA/J	MGP_CBAJ_G0033464	protein coding gene	Chr8:83645992-83959419 (-)
DBA/2J	MGP_DBA2J_G0033618	protein coding gene	Chr8:74425985-74688867 (-)
FVB/NJ	MGP_FVBNJ_G0033563	protein coding gene	Chr8:73423356-73685345 (-)
LP/J	MGP_LPJ_G0033707	protein coding gene	Chr8:77873337-78154459 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033606	protein coding gene	Chr8:86306533-86593569 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034313	protein coding gene	Chr8:76963712-77240011 (-)
PWK/PhJ	MGP_PWKPhJ_G0032520	protein coding gene	Chr8:73662717-73924930 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032358	protein coding gene	Chr8:75798484-76080524 (-)
WSB/EiJ	MGP_WSBEiJ_G0032929	protein coding gene	Chr8:77288350-77565596 (-)

Human Ortholog

ARHGAP10, Rho GTPase activating protein 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGAP10, Rho GTPase activating protein 10
Synonyms

GRAF2, PS-GAP, PSGAP
Links

HGNC:26099

NCBI Gene ID: 79658

neXtProt AC: NX_A1A4S6

UniProt: A1A4S6
Chr Location

4q31.23; chr4:147732063-148072776 (+) GRCh38

MGI Vertebrate Homology

Arhgap10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARHGAP10
Gene Tree

Arhgap10

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

5
Targeted

2
Genomic Mutations

1 involving Arhgap10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced allele exhibit paraparesis, ataxic hindlimbs and splaying of hindlimbs.

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All GO Annotations

17
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

748
Tissues

19
cDNA Data

32
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ARHGAP10

Xenbase arhgap10

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All Sequences

71
RefSeq

30
UniProt

3
CCDS

CCDS22425.1, CCDS90420.1, CCDS90421.1

Ensembl

ENSMUSG00000037148 (Evidence)
NCBI Gene

78514

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037148	Ensembl Gene Model \| MGI Sequence Detail	267588	C57BL/6J	± kb
transcript	ENSMUST00000076316	Ensembl \| MGI Sequence Detail	3084	Not Applicable
polypeptide	ENSMUSP00000075658	Ensembl \| MGI Sequence Detail	786	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000002211 Rho GTPase-activating protein 10

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR004148 BAR domain

IPR035485 GRAF2, SH3 domain

IPR047234 GRAF family

IPR047225 GRAF, PH domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR000198 Rho GTPase-activating protein domain

IPR008936 Rho GTPase activation protein

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 34

Genomic 1

cDNA 32

Primer pair 1

Microarray probesets 2

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arhgap10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr81838	Chr8:78244578-78244608 (-)	-11 bp
Tssr81837	Chr8:78244527-78244567 (-)	35 bp
Tssr81836	Chr8:78244504-78244521 (-)	69 bp
Tssr81835	Chr8:78203841-78203850 (-)	40,736 bp
Tssr81834	Chr8:78192689-78192700 (-)	51,887 bp
Tssr81833	Chr8:78178716-78178720 (-)	65,864 bp
Tssr81832	Chr8:78159884-78159895 (-)	84,692 bp
Tssr81831	Chr8:78114118-78114131 (-)	130,457 bp
Tssr81830	Chr8:78114028-78114046 (-)	130,545 bp
Tssr81829	Chr8:78113934-78113953 (-)	130,638 bp
Tssr81828	Chr8:78102848-78102852 (-)	141,732 bp
Tssr81827	Chr8:78037566-78037576 (-)	207,011 bp
Tssr81826	Chr8:78016585-78016607 (-)	227,986 bp
Tssr81825	Chr8:78013531-78013535 (-)	231,049 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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