Adgra2 MGI Mouse Gene Detail - MGI:1925810 - adhesion G protein-coupled receptor A2

Symbol

Adgra2
Name

adhesion G protein-coupled receptor A2
Synonyms

8430414O08Rik, 9530074E10Rik, Gpr124, mKIAA1531, Tem5

Feature Type

protein coding gene
IDs

MGI:1925810
NCBI Gene: 78560
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr8:27575611-27613464 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 15.91 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

1074 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925810	protein coding gene	Chr8:27575546-27613464 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033501	protein coding gene	Chr8:25269469-25311055 (+)
A/J	MGP_AJ_G0033481	protein coding gene	Chr8:24303588-24342262 (+)
AKR/J	MGP_AKRJ_G0033406	protein coding gene	Chr8:25108379-25146203 (+)
BALB/cJ	MGP_BALBcJ_G0033477	protein coding gene	Chr8:24460795-24501358 (+)
C3H/HeJ	MGP_C3HHeJ_G0033191	protein coding gene	Chr8:25326541-25367853 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033993	protein coding gene	Chr8:26248903-26289597 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030943	protein coding gene	Chr8:21556219-21594023 (+)
CAST/EiJ	MGP_CASTEiJ_G0032517	protein coding gene	Chr8:24814669-24855331 (+)
CBA/J	MGP_CBAJ_G0033166	protein coding gene	Chr8:27286379-27327985 (+)
DBA/2J	MGP_DBA2J_G0033321	protein coding gene	Chr8:24269049-24308168 (+)
FVB/NJ	MGP_FVBNJ_G0033265	protein coding gene	Chr8:24079746-24121037 (+)
LP/J	MGP_LPJ_G0033410	protein coding gene	Chr8:25223528-25263187 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033308	protein coding gene	Chr8:26728371-26768937 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034012	protein coding gene	Chr8:25092571-25130340 (+)
PWK/PhJ	MGP_PWKPhJ_G0032228	protein coding gene	Chr8:23929350-23968114 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032062	protein coding gene	Chr8:24478559-24516336 (+)
WSB/EiJ	MGP_WSBEiJ_G0032633	protein coding gene	Chr8:25273936-25314269 (+)

Human Ortholog

ADGRA2, adhesion G protein-coupled receptor A2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADGRA2, adhesion G protein-coupled receptor A2
Synonyms

GPR124, TEM5
Links

HGNC:17849

NCBI Gene ID: 25960

neXtProt AC: NX_Q96PE1

UniProt: Q96PE1
Chr Location

8p11.23; chr8:37784191-37844896 (+) GRCh38

MGI Vertebrate Homology

Adgra2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADGRA2
Gene Tree

Adgra2

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Phenotype Summary

30 phenotypes from 6 alleles in 6 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

1
Gene trapped

5
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for null mutations display fetal or perinatal lethality with CNS hemorrhage and angiogenic arrest in the CNS.

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All GO Annotations

31
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

771
Tissues

49
cDNA Data

11
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adgra2

ZFIN adgra2

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All Sequences

56
RefSeq

10
UniProt

5
CCDS

CCDS22210.2

Ensembl

ENSMUSG00000031486 (Evidence)
NCBI Gene

78560

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031486	Ensembl Gene Model \| MGI Sequence Detail	37854	C57BL/6J	± kb
transcript	ENSMUST00000033876	Ensembl \| MGI Sequence Detail	5760	Not Applicable
polypeptide	ENSMUSP00000033876	Ensembl \| MGI Sequence Detail	1336	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000031416 adhesion G protein-coupled receptor A2

(term hierarchy)
InterPro Domains

IPR051963 Adhesion G protein-coupled receptor A

IPR000483 Cysteine-rich flanking region, C-terminal

IPR046338 GAIN domain superfamily

IPR001879 GPCR, family 2, extracellular hormone receptor domain

IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily

IPR017981 GPCR, family 2-like, 7TM

IPR000832 GPCR, family 2, secretin-like

IPR017983 GPCR, family 2, secretin-like, conserved site

IPR000203 GPS motif

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype
GlyGen

Q91ZV8 10 sites, 6 N-linked glycans (7 sites)

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All nucleic 13

cDNA 11

Primer pair 1

Other 1

Microarray probesets 3

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MGI:1918709

Summaries

All 57

Developmental Gene Expression 10

Gene Ontology 12

Phenotypes 19
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:324709 Wang Y, et al., The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development. Development. 2022 May 1;149(9):dev200340

TSS for Adgra2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76764	Chr8:27575548-27575608 (+)	-33 bp
Tssr76765	Chr8:27575611-27575620 (+)	5 bp
Tssr76766	Chr8:27575863-27575916 (+)	279 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24