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Fhod3 Gene Detail
Summary
  • Symbol
    Fhod3
  • Name
    formin homology 2 domain containing 3
  • Synonyms
    A930009H06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925847
    NCBI Gene: 225288
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:24841680-25266558 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 13.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    12990 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925847
 protein coding gene Chr18:24841445-25266564 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024206
 protein coding gene Chr18:22487082-22938832 (+)
A/J MGP_AJ_G0024171
 protein coding gene Chr18:21850569-22281123 (+)
AKR/J MGP_AKRJ_G0024140
 protein coding gene Chr18:22493578-22944843 (+)
BALB/cJ MGP_BALBcJ_G0024171
 protein coding gene Chr18:21915197-22343632 (+)
C3H/HeJ MGP_C3HHeJ_G0023939
 protein coding gene Chr18:22437991-22887439 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024613
 protein coding gene Chr18:23412303-23861876 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022055
 protein coding gene Chr18:21694683-22110804 (+)
CAST/EiJ MGP_CASTEiJ_G0023413
 protein coding gene Chr18:22225234-22689613 (+)
CBA/J MGP_CBAJ_G0023907
 protein coding gene Chr18:24027504-24512913 (+)
DBA/2J MGP_DBA2J_G0024039
 protein coding gene Chr18:21499328-21930286 (+)
FVB/NJ MGP_FVBNJ_G0024005
 protein coding gene Chr18:21281791-21712322 (+)
LP/J MGP_LPJ_G0024120
 protein coding gene Chr18:22632569-23073620 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024033
 protein coding gene Chr18:25042532-25523193 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024661
 protein coding gene Chr18:22267827-22718867 (+)
PWK/PhJ MGP_PWKPhJ_G0023157
 protein coding gene Chr18:21649255-22080839 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022966
 protein coding gene Chr18:22494273-22939258 (+)
WSB/EiJ MGP_WSBEiJ_G0023477
 protein coding gene Chr18:22154155-22601011 (+)



Homology
more
  • Human Ortholog
    FHOD3, formin homology 2 domain containing 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FHOD3, formin homology 2 domain containing 3
  • Synonyms
    CMH28, FHOS2, Formactin2
  • Links
    NCBI Gene ID: 80206
    neXtProt AC: NX_Q2V2M9
    UniProt: Q2V2M9

  • Chr Location
    18q12.2; chr18:36297713-36780220 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FHOD3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 3 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out reporter allele exhibit abnormal premyofibril maturation, impaired heart development, pericardial effusion and embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1020
  • Tissues
    101
  • cDNA Data
    52
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034295 Ensembl Gene Model | MGI Sequence Detail 424879 C57BL/6J ±  kb
    transcript ENSMUST00000037097 Ensembl | MGI Sequence Detail 5409 Not Applicable  
    polypeptide ENSMUSP00000041361 Ensembl | MGI Sequence Detail 1578 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007517 FH1/FH2 domain-containing protein 3
      (term hierarchy)
    • InterPro Domains
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR014767 Diaphanous autoregulatory (DAD) domain
      IPR041387 FHOD1, N-terminal GTPase-binding domain
      IPR015425 Formin, FH2 domain
      IPR042201 Formin, FH2 domain superfamily
      IPR014768 Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
    • GlyGen
      Q76LL6 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 63
      cDNA 52
      Primer pair 10
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 11
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:350358 Boussaty EC, et al., Altered Fhod3 expression involved in progressive high-frequency hearing loss via dysregulation of actin polymerization stoichiometry in the cuticular plate. PLoS Genet. 2024 Mar;20(3):e1011211
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory