Uvrag MGI Mouse Gene Detail - MGI:1925860 - UV radiation resistance associated gene

Symbol

Uvrag
Name

UV radiation resistance associated gene
Synonyms

9530039D02Rik, Uvragl

Feature Type

protein coding gene
IDs

MGI:1925860
NCBI Gene: 78610
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:98535949-98790373 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 53.92 cM
Mapping Data

2 experiments

SNPs within 2kb

6711 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925860	protein coding gene	Chr7:98534228-98790373 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032544	protein coding gene	Chr7:101647614-101913740 (-)
A/J	MGP_AJ_G0032518	protein coding gene	Chr7:99130896-99385674 (-)
AKR/J	MGP_AKRJ_G0032454	protein coding gene	Chr7:101487512-101746738 (-)
BALB/cJ	MGP_BALBcJ_G0032529	protein coding gene	Chr7:98814322-99074573 (-)
C3H/HeJ	MGP_C3HHeJ_G0032244	protein coding gene	Chr7:101831760-102102925 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033027	protein coding gene	Chr7:105568716-105835671 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030022	protein coding gene	Chr7:101557860-101823700 (-)
CAST/EiJ	MGP_CASTEiJ_G0031571	protein coding gene	Chr7:93358355-93639177 (-)
CBA/J	MGP_CBAJ_G0032211	protein coding gene	Chr7:109160235-109461447 (-)
DBA/2J	MGP_DBA2J_G0032363	protein coding gene	Chr7:97459267-97726042 (-)
FVB/NJ	MGP_FVBNJ_G0032320	protein coding gene	Chr7:97260193-97515826 (-)
LP/J	MGP_LPJ_G0032452	protein coding gene	Chr7:102973071-103234101 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032352	protein coding gene	Chr7:110668558-110933980 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033049	protein coding gene	Chr7:100746823-101013534 (-)
PWK/PhJ	MGP_PWKPhJ_G0031289	protein coding gene	Chr7:90544035-90812700 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031132	protein coding gene	Chr7:88041782-88313949 (-)
WSB/EiJ	MGP_WSBEiJ_G0031688	protein coding gene	Chr7:101420108-101686205 (-)

Human Ortholog

UVRAG, UV radiation resistance associated

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UVRAG, UV radiation resistance associated
Synonyms

DHTX, p63, VPS38
Links

HGNC:12640

NCBI Gene ID: 7405

neXtProt AC: NX_Q9P2Y5

UniProt: Q9P2Y5
Chr Location

11q13.5; chr11:75815210-76144232 (+) GRCh38

MGI Vertebrate Homology

Uvrag stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UVRAG
Gene Tree

Uvrag

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

22
Radiation induced

1
Targeted

3
Transposon induced

1
Genomic Mutations

2 involving Uvrag
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a transposon induced knock-out allele are viable and fertile but exhibit impaired autophagic flux, autophagosome accumulation in the heart, and age-related cardiomyopathy associated with compromised cardiac function and heart inflammation.

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All GO Annotations

59
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

741
Tissues

3
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase uvrag

ZFIN uvrag

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All Sequences

72
RefSeq

8
UniProt

5
CCDS

CCDS21476.1

Ensembl

ENSMUSG00000035354 (Evidence)
NCBI Gene

78610

			Length	Strain/Species	Flank
genomic	78610	NCBI Gene Model \| MGI Sequence Detail	254425	C57BL/6J	± kb
transcript	NM_178635	RefSeq \| MGI Sequence Detail	3438	C57BL/6
polypeptide	Q8K245	UniProt \| EBI \| MGI Sequence Detail	698	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017214 UV radiation resistance-associated gene protein

(term hierarchy)
PDB

5YR0
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR018791 UV radiation resistance protein/autophagy-related protein 14

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All nucleic 17

cDNA 17

Microarray probesets 3

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MGI:2142020, MGI:2142291, MGI:892963

Summaries

All 60

Developmental Gene Expression 2

Gene Ontology 11

Phenotypes 23
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Uvrag:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73659	Chr7:98790473-98790501 (-)	-114 bp
Tssr73658	Chr7:98790275-98790356 (-)	57 bp
Tssr73657	Chr7:98780952-98780954 (-)	9,420 bp
Tssr73656	Chr7:98765964-98765969 (-)	24,406 bp
Tssr73655	Chr7:98699149-98699190 (-)	91,203 bp
Tssr73654	Chr7:98669639-98669646 (-)	120,730 bp
Tssr73653	Chr7:98642756-98642758 (-)	147,616 bp
Tssr73652	Chr7:98625181-98625204 (-)	165,180 bp
Tssr73651	Chr7:98592560-98592566 (-)	197,810 bp
Tssr73650	Chr7:98580406-98580409 (-)	209,965 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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