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Arhgef19 Gene Detail
Summary
  • Symbol
    Arhgef19
  • Name
    Rho guanine nucleotide exchange factor 19
  • Synonyms
    6430573B13Rik, WGEF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925912
    NCBI Gene: 213649
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:140966810-140984875 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 73.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    564 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925912
 protein coding gene Chr4:140966810-140985226 (+)
129S1/SvImJ ENSMUSG00200044077
 protein coding gene Chr4:134394582-134405948 (+)
A/J ENSMUSG00195031970
 protein coding gene Chr4:135739367-135750765 (+)
AKR/J ENSMUSG00220044394
 protein coding gene Chr4:134740189-134751586 (+)
BALB/cJ ENSMUSG00180041121
 protein coding gene Chr4:133380503-133391897 (+)
C3H/HeJ ENSMUSG00175038039
 protein coding gene Chr4:134407034-134418427 (+)
C57BL/6NJ ENSMUSG00215050002
 protein coding gene Chr4:135924930-135936319 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026737
 protein coding gene Chr4:130917730-130936295 (+)
CAST/EiJ ENSTCUG00005012757
 protein coding gene Chr4:135359792-135371179 (+)
CBA/J ENSMUSG00210026537
 protein coding gene Chr4:134030982-134042371 (+)
DBA/2J ENSMUSG00185048241
 protein coding gene Chr4:135540520-135551922 (+)
FVB/NJ ENSMUSG00205038621
 protein coding gene Chr4:133791629-133803050 (+)
JF1/MsJ ENSUMUG00000042046
 protein coding gene Chr4:136228120-136239523 (+)
LP/J ENSMUSG00230035709
 protein coding gene Chr4:139325880-139345070 (+)
NOD/ShiLtJ ENSMUSG00190022836
 protein coding gene Chr4:133787213-133798610 (+)
NZO/HlLtJ ENSMUSG00225009439
 protein coding gene Chr4:145271590-145290804 (+)
PWK/PhJ ENSLUMG00010039614
 protein coding gene Chr4:133225946-133237349 (+)
SPRET/EiJ ENSMSPG00010029576
 protein coding gene Chr4:135271775-135283878 (+)
WSB/EiJ ENSIUOG00005039529
 protein coding gene Chr4:133673462-133684871 (+)



Homology
more
  • Human Ortholog
    ARHGEF19, Rho guanine nucleotide exchange factor 19
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF19, Rho guanine nucleotide exchange factor 19
  • Synonyms
    WGEF
  • Links
    NCBI Gene ID: 128272
    UniProt: Q8IW93

  • Chr Location
    1p36.13; chr1:16197854-16212893 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    653
  • Tissues
    13
  • cDNA Data
    30
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028919 Ensembl Gene Model | MGI Sequence Detail 18066 C57BL/6J ±  kb
transcript ENSMUST00000006618 Ensembl | MGI Sequence Detail 3414 Not Applicable  
polypeptide ENSMUSP00000006618 Ensembl | MGI Sequence Detail 802 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 30
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 36
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:267222 Kimura-Yoshida C, et al., Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis. Nat Commun. 2018 Oct 3;9(1):4059
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory