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Pus7 Gene Detail
Summary
  • Symbol
    Pus7
  • Name
    pseudouridylate synthase 7
  • Synonyms
    C330017I15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925947
    NCBI Gene: 78697
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:23945646-23988709 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 10.42 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1775 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925947
 protein coding gene Chr5:23945163-23988709 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029331
 protein coding gene Chr5:21421900-21468666 (-)
A/J MGP_AJ_G0029297
 protein coding gene Chr5:20706180-20748957 (-)
AKR/J MGP_AKRJ_G0029248
 protein coding gene Chr5:21545843-21588555 (-)
BALB/cJ MGP_BALBcJ_G0029308
 protein coding gene Chr5:21212530-21257081 (-)
C3H/HeJ MGP_C3HHeJ_G0029028
 protein coding gene Chr5:21631531-21676897 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029761
 protein coding gene Chr5:22892175-22941130 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026999
 protein coding gene Chr5:18663213-18706928 (-)
CAST/EiJ MGP_CASTEiJ_G0028440
 protein coding gene Chr5:20810122-20861342 (-)
CBA/J MGP_CBAJ_G0028995
 protein coding gene Chr5:23212031-23265537 (-)
DBA/2J MGP_DBA2J_G0029146
 protein coding gene Chr5:20986718-21031518 (-)
FVB/NJ MGP_FVBNJ_G0029104
 protein coding gene Chr5:20377787-20421268 (-)
LP/J MGP_LPJ_G0029230
 protein coding gene Chr5:21810212-21849209 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029133
 protein coding gene Chr5:24395381-24446532 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029795
 protein coding gene Chr5:21140836-21189466 (-)
PWK/PhJ MGP_PWKPhJ_G0028163
 protein coding gene Chr5:20052345-20097199 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027995
 protein coding gene Chr5:20518059-20565392 (-)
WSB/EiJ MGP_WSBEiJ_G0028520
 protein coding gene Chr5:21227336-21283287 (-)



Homology
more
  • Human Ortholog
    PUS7, pseudouridine synthase 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PUS7, pseudouridine synthase 7
  • Synonyms
    IDDABS
  • Links
    NCBI Gene ID: 54517
    neXtProt AC: NX_Q96PZ0
    UniProt: Q96PZ0

  • Chr Location
    7q22.3; chr7:105439661-105522271 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PUS7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    1
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057541 Ensembl Gene Model | MGI Sequence Detail 43064 C57BL/6J ±  kb
    transcript ENSMUST00000148618 Ensembl | MGI Sequence Detail 3266 Not Applicable  
    polypeptide ENSMUSP00000114588 Ensembl | MGI Sequence Detail 666 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013499 pseudouridylate synthase 7
      (term hierarchy)
    • EC
      5.4.99.-
    • InterPro Domains
      IPR020103 Pseudouridine synthase, catalytic domain superfamily
      IPR001656 Pseudouridine synthase, TruD
      IPR042214 Pseudouridine synthase, TruD, catalytic domain
      IPR020119 Pseudouridine synthase TruD, conserved site
      IPR011760 Pseudouridine synthase, TruD, insertion domain
    • GlyGen
      Q91VU7 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory