Platr4 MGI Mouse Gene Detail - MGI:1925956 - pluripotency associated transcript 4

Symbol

Platr4
Name

pluripotency associated transcript 4
Synonyms

C430002E04Rik

Feature Type

lncRNA gene
IDs

MGI:1925956
NCBI Gene: 78706
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr3:41442116-41447634 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 19.85 cM
Mapping Data

2 experiments

SNPs within 2kb

242 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925956	lncRNA gene	Chr3:41415560-41447634 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0006175	lincRNA gene	Chr3:39489352-39498528 (-)
A/J	MGP_AJ_G0006167	lincRNA gene	Chr3:38523796-38532994 (-)
AKR/J	MGP_AKRJ_G0006143	lincRNA gene	Chr3:39254839-39263992 (-)
BALB/cJ	MGP_BALBcJ_G0006143	lincRNA gene	Chr3:38297141-38306317 (-)
C3H/HeJ	MGP_C3HHeJ_G0006093	lincRNA gene	Chr3:39373936-39383119 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0006305	lincRNA gene	Chr3:41118356-41127524 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0005616	lincRNA gene	Chr3:36030722-36039798 (-)
CAST/EiJ	MGP_CASTEiJ_G0006028	lincRNA gene	Chr3:39259808-39268932 (-)
CBA/J	MGP_CBAJ_G0006078	lincRNA gene	Chr3:42280824-42290002 (-)
DBA/2J	MGP_DBA2J_G0006097	lincRNA gene	Chr3:37989570-37998744 (-)
FVB/NJ	MGP_FVBNJ_G0006121	lincRNA gene	Chr3:37363580-37372743 (-)
LP/J	MGP_LPJ_G0006179	lincRNA gene	Chr3:40231566-40240732 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0006111	lincRNA gene	Chr3:44733016-44742184 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0006309	lincRNA gene	Chr3:39126263-39135439 (-)
PWK/PhJ	MGP_PWKPhJ_G0005973	lincRNA gene	Chr3:37670111-37679317 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0005882	lincRNA gene	Chr3:38790324-38799476 (-)
WSB/EiJ	MGP_WSBEiJ_G0006075	lincRNA gene	Chr3:39135744-39147625 (-)

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Gene Tree

Platr4

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References

1 with disease annotations

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

8
Radiation induced

2
Genomic Mutations

2 involving Platr4
Find Mice (IMSR)

0 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit myocardial atrophy, valve mucinous degeneration, left ventricular hypertrophy, reduced cardiac output and heart rate, with 60% showing sudden heart failure.

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Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

726
Tissues

18
cDNA Data

4
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

30
RefSeq

1

Ensembl

ENSMUSG00000097639 (Evidence)
NCBI Gene

78706

Representative Sequences				Length	Strain/Species	Flank
	genomic	78706	NCBI Gene Model \| MGI Sequence Detail	5519	C57BL/6J	± kb
	transcript	NR_040385	RefSeq \| MGI Sequence Detail	2168	C57BL/6

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All nucleic 6

cDNA 4

Primer pair 1

Other 1

Microarray probesets 1

Summaries

All 24

Developmental Gene Expression 1

Diseases 1

Phenotypes 11
Earliest

J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
Latest

J:331476 Hazra R, et al., Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment. Dev Cell. 2022 Nov 7;57(21):2450-2468.e7

TSS for Platr4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr33077	Chr3:41449379-41449386 (-)	-1,749 bp
Tssr33076	Chr3:41449331-41449340 (-)	-1,702 bp
Tssr33075	Chr3:41447612-41447637 (-)	9 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24