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Spink8 Gene Detail
Summary
  • Symbol
    Spink8
  • Name
    serine peptidase inhibitor, Kazal type 8
  • Synonyms
    C630041L24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925959
    NCBI Gene: 78709
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:109641348-109655701 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.77 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    601 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925959
 protein coding gene Chr9:109641271-109655701 (+)
129S1/SvImJ ENSMUSG00200038819
 protein coding gene Chr9:106734507-106749103 (+)
A/J ENSMUSG00195043850
 protein coding gene Chr9:106026896-106041407 (+)
AKR/J ENSMUSG00220026335
 protein coding gene Chr9:106362632-106377139 (+)
BALB/cJ ENSMUSG00180027327
 protein coding gene Chr9:106481823-106496330 (+)
C3H/HeJ ENSMUSG00175032925
 protein coding gene Chr9:106697716-106712221 (+)
C57BL/6NJ ENSMUSG00215014855
 protein coding gene Chr9:106578033-106592386 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032720
 protein coding gene Chr9:105100324-105113388 (+)
CAST/EiJ ENSTCUG00005028248
 protein coding gene Chr9:106396879-106411944 (+)
CBA/J ENSMUSG00210030670
 protein coding gene Chr9:106411169-106425262 (+)
DBA/2J ENSMUSG00185041190
 protein coding gene Chr9:106745718-106760232 (+)
FVB/NJ ENSMUSG00205048961
 protein coding gene Chr9:106676078-106690656 (+)
JF1/MsJ ENSUMUG00000028717
 protein coding gene Chr9:106513476-106527589 (+)
LP/J ENSMUSG00230043485
 protein coding gene Chr9:106866723-106881318 (+)
NOD/ShiLtJ ENSMUSG00190041158
 protein coding gene Chr9:106333344-106347850 (+)
NZO/HlLtJ ENSMUSG00225024188
 protein coding gene Chr9:107116227-107130767 (+)
PWK/PhJ ENSLUMG00010036070
 protein coding gene Chr9:106529058-106543191 (+)
SPRET/EiJ ENSMSPG00010042865
 protein coding gene Chr9:108315091-108334704 (+)
WSB/EiJ ENSIUOG00005045532
 protein coding gene Chr9:105791828-105806366 (+)



Homology
more
  • Human Ortholog
    SPINK8, serine peptidase inhibitor Kazal type 8 (putative)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPINK8, serine peptidase inhibitor Kazal type 8 (putative)
  • Links
    NCBI Gene ID: 646424
    UniProt: P0C7L1

  • Chr Location
    3p21.31; chr3:48306842-48333661 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    5 phenotype references
Male mice homozygous for a mutation are viable and show normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    626
  • Tissues
    27
  • cDNA Data
    11
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050074 Ensembl Gene Model | MGI Sequence Detail 14354 C57BL/6J ±  kb
transcript ENSMUST00000198988 Ensembl | MGI Sequence Detail 768 Not Applicable  
polypeptide ENSMUSP00000142586 Ensembl | MGI Sequence Detail 105 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:234235 Miyata H, et al., Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7704-10
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory