Cpxm2 Gene Detail

Summary

• Symbol
  Cpxm2
• Name
  carboxypeptidase X, M14 family member 2
• Synonyms
  4632435C11Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1926006
  NCBI Gene: 55987
• Alliance
  gene page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  Chr7:131634416-131756468 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 75.60 cM, cytoband F4
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  3753 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926006	protein coding gene	Chr7:131634416-131756483 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033110	protein coding gene	Chr7:136722235-136838641 (-)
A/J	MGP_AJ_G0033092	protein coding gene	Chr7:132957619-133071640 (-)
AKR/J	MGP_AKRJ_G0033024	protein coding gene	Chr7:136498584-136612202 (-)
BALB/cJ	MGP_BALBcJ_G0033093	protein coding gene	Chr7:132642300-132752021 (-)
C3H/HeJ	MGP_C3HHeJ_G0032807	protein coding gene	Chr7:136339728-136453001 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033604	protein coding gene	Chr7:141924538-142038474 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030575	protein coding gene	Chr7:134222924-134338963 (-)
CAST/EiJ	MGP_CASTEiJ_G0032137	protein coding gene	Chr7:128210897-128320499 (-)
CBA/J	MGP_CBAJ_G0032780	protein coding gene	Chr7:146754987-146871613 (-)
DBA/2J	MGP_DBA2J_G0032932	protein coding gene	Chr7:130972550-131083282 (-)
FVB/NJ	MGP_FVBNJ_G0032885	protein coding gene	Chr7:130798981-130909309 (-)
LP/J	MGP_LPJ_G0033026	protein coding gene	Chr7:138204523-138327792 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032917	protein coding gene	Chr7:147718478-147830587 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033624	protein coding gene	Chr7:135488998-135601939 (-)
PWK/PhJ	MGP_PWKPhJ_G0031843	protein coding gene	Chr7:123979785-124093172 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031689	protein coding gene	Chr7:122275494-122389335 (-)
WSB/EiJ	MGP_WSBEiJ_G0032248	protein coding gene	Chr7:136392964-136505869 (-)

Homology

• Human Ortholog
  CPXM2, carboxypeptidase X, M14 family member 2

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  CPXM2, carboxypeptidase X, M14 family member 2
  
• Synonyms
  CPX2, UNQ676
• Links
  HGNC:26977

  NCBI Gene ID: 119587

  neXtProt AC: NX_Q8N436

  UniProt: Q8N436

  
  
• Chr Location
  10q26.13; chr10:123706207-123944104 (-)  GRCh38

---

• MGI Vertebrate Homology
  Cpxm2 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: CPXM2
• Gene Tree
  Cpxm2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from 1 allele in 1 genetic background
  7 phenotype references
  

• All Mutations and Alleles
  4
• Endonuclease-mediated
  2
• Targeted
  2
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  47 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a null allele display attenuated cardiac responses to induce hypertension.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  4
• GO References
  2

Expression

• Assay Results
  749
• Tissues
  6
• cDNA Data
  17
• Literature Summary
  7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase cpxm2

Sequences &
Gene Models

• All Sequences
  47
• RefSeq
  12
• UniProt
  3
• CCDS
  CCDS21921.1

• Ensembl
  ENSMUSG00000030862 (Evidence)
• NCBI Gene
  55987

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000030862	Ensembl Gene Model | MGI Sequence Detail	122053	C57BL/6J
transcript	ENSMUST00000033149	Ensembl | MGI Sequence Detail	3498	Not Applicable
polypeptide	ENSMUSP00000033149	Ensembl | MGI Sequence Detail	764	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000005840 inactive carboxypeptidase-like protein X2
  (term hierarchy)
• InterPro Domains
  IPR008969 Carboxypeptidase-like, regulatory domain superfamily
  IPR000421 Coagulation factor 5/8 C-terminal domain
  IPR008979 Galactose-binding-like domain superfamily
  IPR000834 Peptidase M14, carboxypeptidase A
  IPR050753 Peptidase M14 domain-containing protein
• GlyGen
  Q9D2L5 5 sites, 1 N-linked glycan (3 sites)

Molecular
Reagents

• All nucleic 21

  cDNA 19

  Primer pair 1

  Other 1

  
  

  Microarray probesets 5

References

• Summaries
  All 34

  Developmental Gene Expression 7

  Gene Ontology 2

  Phenotypes 7
• Earliest
  J:50715 Xin X, et al., Identification of mouse CPX-2, a novel member of the metallocarboxypeptidase gene family: cDNA cloning, mRNA distribution, and protein expression and characterization. DNA Cell Biol. 1998 Oct;17(10):897-909
• Latest
  J:345349 Grabowski K, et al., Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension. Hypertens Res. 2022 Feb;45(2):292-307

TSS for Cpxm2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75190	Chr7:131756446-131756474 (-)	8 bp
Tssr75189	Chr7:131756394-131756441 (-)	50 bp
Tssr75188	Chr7:131756373-131756380 (-)	91 bp
Tssr75187	Chr7:131756347-131756356 (-)	116 bp