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Eml4 Gene Detail
Summary
  • Symbol
    Eml4
  • Name
    echinoderm microtubule associated protein like 4
  • Synonyms
    4930443C24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926048
    NCBI Gene: 78798
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:83658360-83787790 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 52.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2642 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926048
 protein coding gene Chr17:83658341-83787790 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024072
 protein coding gene Chr17:86427792-86561092 (+)
A/J MGP_AJ_G0024031
 protein coding gene Chr17:83709038-83834996 (+)
AKR/J MGP_AKRJ_G0024000
 protein coding gene Chr17:85063766-85194135 (+)
BALB/cJ MGP_BALBcJ_G0024032
 protein coding gene Chr17:83564769-83698749 (+)
C3H/HeJ MGP_C3HHeJ_G0023797
 protein coding gene Chr17:85903209-86040226 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024477
 protein coding gene Chr17:89534137-89670835 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021916
 protein coding gene Chr17:78935779-79053836 (+)
CAST/EiJ MGP_CASTEiJ_G0023276
 protein coding gene Chr17:86621060-86757487 (+)
CBA/J MGP_CBAJ_G0023771
 protein coding gene Chr17:93211395-93351589 (+)
DBA/2J MGP_DBA2J_G0023899
 protein coding gene Chr17:82177803-82308888 (+)
FVB/NJ MGP_FVBNJ_G0023865
 protein coding gene Chr17:81678571-81811250 (+)
LP/J MGP_LPJ_G0023983
 protein coding gene Chr17:87174595-87307238 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023893
 protein coding gene Chr17:93351014-93491091 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024522
 protein coding gene Chr17:85546159-85677151 (+)
PWK/PhJ MGP_PWKPhJ_G0023021
 protein coding gene Chr17:81748680-81873866 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022832
 protein coding gene Chr17:82343304-82465369 (+)
WSB/EiJ MGP_WSBEiJ_G0023343
 protein coding gene Chr17:86396052-86528311 (+)



Homology
more
  • Human Ortholog
    EML4, EMAP like 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EML4, EMAP like 4
  • Synonyms
    C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120
  • Links
    NCBI Gene ID: 27436
    neXtProt AC: NX_Q9HC35
    UniProt: Q9HC35

  • Chr Location
    2p21; chr2:42169353-42332548 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    55
  • cDNA Data
    200
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032624 Ensembl Gene Model | MGI Sequence Detail 129431 C57BL/6J ±  kb
transcript ENSMUST00000096766 Ensembl | MGI Sequence Detail 5441 Not Applicable  
polypeptide ENSMUSP00000094528 Ensembl | MGI Sequence Detail 988 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000007059 echinoderm microtubule-associated protein-like 4
    (term hierarchy)
  • InterPro Domains
    IPR005108 HELP motif
    IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
    IPR001680 WD40 repeat
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    IPR050630 WD repeat Echinoderm Microtubule-associated Protein-like
  • GlyGen
    Q3UMY5 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 205
    cDNA 201
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146898
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory