Ak7 MGI Mouse Gene Detail - MGI:1926051

Symbol

Ak7
Name

adenylate kinase 7
Synonyms

4930502N02Rik

Feature Type

protein coding gene
IDs

MGI:1926051
NCBI Gene: 78801
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr12:105672235-105748706 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 55.95 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

2390 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926051	protein coding gene	Chr12:105670115-105748706 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020095	protein coding gene	Chr12:107589956-107680075 (+)
A/J	MGP_AJ_G0020049	protein coding gene	Chr12:103577604-103654213 (+)
AKR/J	MGP_AKRJ_G0020025	protein coding gene	Chr12:106577734-106657830 (+)
BALB/cJ	MGP_BALBcJ_G0020035	protein coding gene	Chr12:103989114-104066962 (+)
C3H/HeJ	MGP_C3HHeJ_G0019837	protein coding gene	Chr12:107004817-107092403 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020480	protein coding gene	Chr12:110903442-110991889 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018092	protein coding gene	Chr12:100168256-100245497 (+)
CAST/EiJ	MGP_CASTEiJ_G0019379	protein coding gene	Chr12:101813777-101900880 (+)
CBA/J	MGP_CBAJ_G0019804	protein coding gene	Chr12:115306645-115409793 (+)
DBA/2J	MGP_DBA2J_G0019921	protein coding gene	Chr12:103096867-103177721 (+)
FVB/NJ	MGP_FVBNJ_G0019906	protein coding gene	Chr12:101882780-101960276 (+)
LP/J	MGP_LPJ_G0019996	protein coding gene	Chr12:107485286-107569463 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019944	protein coding gene	Chr12:118702433-118794202 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020509	protein coding gene	Chr12:105965066-106057603 (+)
PWK/PhJ	MGP_PWKPhJ_G0019138	protein coding gene	Chr12:97687365-97762618 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018942	protein coding gene	Chr12:100188364-100274496 (+)
WSB/EiJ	MGP_WSBEiJ_G0019436	protein coding gene	Chr12:106918424-107006617 (+)

Human Ortholog

AK7, adenylate kinase 7

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AK7, adenylate kinase 7
Synonyms

AK 7, CFAP75, FAP75, SPGF27
Links

HGNC:20091

NCBI Gene ID: 122481

neXtProt AC: NX_Q96M32

UniProt: Q96M32
Chr Location

14q32.2; chr14:96392128-96489427 (+) GRCh38

MGI Vertebrate Homology

Ak7 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: AK7
Gene Tree

Ak7

Diseases

1 with Ak7 mouse models; 1 with human AK7 associations

Human Disease

Mouse Models

hydrocephalus

IDs

View 1 model

spermatogenic failure 27

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

less

Phenotype Summary

22 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

137
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

133
Transgenic

1
Genomic Mutations

1 involving Ak7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

139 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice exhibit hydrocephalus, rhinitis, sperm defects and most die before 8 weeks of age.

less

All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

7
cDNA Data

6
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ak7

ZFIN ak7b

less

All Sequences

35
RefSeq

4
UniProt

2
CCDS

CCDS49162.1

Ensembl

ENSMUSG00000041323 (Evidence)
NCBI Gene

78801

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041323	Ensembl Gene Model \| MGI Sequence Detail	76472	C57BL/6J	± kb
transcript	ENSMUST00000040876	Ensembl \| MGI Sequence Detail	3099	Not Applicable
polypeptide	ENSMUSP00000043145	Ensembl \| MGI Sequence Detail	723	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000029118 adenylate kinase 7

(term hierarchy)
EC

2.7.4.3, 2.7.4.6
InterPro Domains

IPR047499 Adenylate kinase 7, dimerization/docking domain

IPR000850 Adenylate kinase/UMP-CMP kinase

IPR007858 Dpy-30 motif

IPR036291 NAD(P)-binding domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

less

All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 3

Summaries

All 34

Developmental Gene Expression 1

Diseases 2

Gene Ontology 8

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ak7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114915	Chr12:105672229-105672246 (+)	3 bp
Tssr114916	Chr12:105672263-105672271 (+)	32 bp
Tssr114917	Chr12:105672366-105672417 (+)	157 bp
Tssr114918	Chr12:105700325-105700364 (+)	28,110 bp
Tssr114919	Chr12:105727650-105727686 (+)	55,433 bp
Tssr114920	Chr12:105727705-105727717 (+)	55,476 bp
Tssr114921	Chr12:105742708-105742713 (+)	70,476 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24