Gmip MGI Mouse Gene Detail - MGI:1926066

Symbol

Gmip
Name

Gem-interacting protein
Synonyms

5031419I10Rik

Feature Type

protein coding gene
IDs

MGI:1926066
NCBI Gene: 78816
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr8:70261329-70274520 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 33.88 cM
Mapping Data

1 experiment

SNPs within 2kb

299 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926066	protein coding gene	Chr8:70260912-70274520 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033677	protein coding gene	Chr8:70021866-70035005 (+)
A/J	MGP_AJ_G0033660	protein coding gene	Chr8:67185529-67199886 (+)
AKR/J	MGP_AKRJ_G0033585	protein coding gene	Chr8:69088431-69101553 (+)
BALB/cJ	MGP_BALBcJ_G0033656	protein coding gene	Chr8:67408502-67421662 (+)
C3H/HeJ	MGP_C3HHeJ_G0033366	protein coding gene	Chr8:69744314-69759167 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034173	protein coding gene	Chr8:72683317-72698424 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031117	protein coding gene	Chr8:62012186-62026270 (+)
CAST/EiJ	MGP_CASTEiJ_G0032691	protein coding gene	Chr8:69211202-69227035 (+)
CBA/J	MGP_CBAJ_G0033344	protein coding gene	Chr8:75340114-75353254 (+)
DBA/2J	MGP_DBA2J_G0033498	protein coding gene	Chr8:66911822-66925641 (+)
FVB/NJ	MGP_FVBNJ_G0033439	protein coding gene	Chr8:66004937-66018200 (+)
LP/J	MGP_LPJ_G0033585	protein coding gene	Chr8:70084302-70097503 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033483	protein coding gene	Chr8:77997156-78010241 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034191	protein coding gene	Chr8:69270547-69284732 (+)
PWK/PhJ	MGP_PWKPhJ_G0032399	protein coding gene	Chr8:66194466-66209448 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032235	protein coding gene	Chr8:68251985-68265680 (+)
WSB/EiJ	MGP_WSBEiJ_G0032806	protein coding gene	Chr8:69637866-69652953 (+)

Human Ortholog

GMIP, GEM interacting protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GMIP, GEM interacting protein
Synonyms

ARHGAP46
Links

HGNC:24852

NCBI Gene ID: 51291

neXtProt AC: NX_Q9P107

UniProt: Q9P107
Chr Location

19p13.11; chr19:19629476-19643657 (-) GRCh38

MGI Vertebrate Homology

Gmip stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GMIP
Gene Tree

Gmip

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

3
Genomic Mutations

1 involving Gmip
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

20
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

6
cDNA Data

48
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gmip

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All Sequences

64
RefSeq

17
UniProt

2
CCDS

CCDS22350.1

Ensembl

ENSMUSG00000036246 (Evidence)
NCBI Gene

78816

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036246	Ensembl Gene Model \| MGI Sequence Detail	13192	C57BL/6J	± kb
transcript	ENSMUST00000036074	Ensembl \| MGI Sequence Detail	3933	Not Applicable
polypeptide	ENSMUSP00000045676	Ensembl \| MGI Sequence Detail	971	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008072 GEM-interacting protein

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR046349 C1-like domain superfamily

IPR031160 F-BAR domain

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR051025 Rho GTPase-activating

IPR000198 Rho GTPase-activating protein domain

IPR008936 Rho GTPase activation protein
GlyGen

Q6PGG2 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 49

cDNA 48

Primer pair 1

Microarray probesets 3

Summaries

All 33

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gmip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77672	Chr8:70261322-70261392 (+)	28 bp
Tssr77673	Chr8:70264309-70264322 (+)	2,987 bp
Tssr77674	Chr8:70264544-70264558 (+)	3,222 bp
Tssr77675	Chr8:70264987-70265003 (+)	3,666 bp
Tssr77676	Chr8:70265048-70265065 (+)	3,728 bp
Tssr77677	Chr8:70265299-70265314 (+)	3,978 bp
Tssr77678	Chr8:70269448-70269481 (+)	8,136 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24