Zfp536 MGI Mouse Gene Detail - MGI:1926102

Symbol

Zfp536
Name

zinc finger protein 536
Synonyms

9630010P11Rik, mKIAA0390

Feature Type

protein coding gene
IDs

MGI:1926102
NCBI Gene: 243937
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr7:37017449-37473066 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 24.57 cM
Mapping Data

2 experiments

SNPs within 2kb

12024 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926102	protein coding gene	Chr7:37017448-37473733 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032098	protein coding gene	Chr7:36974878-37297785 (-)
A/J	MGP_AJ_G0032078	protein coding gene	Chr7:35959153-36261746 (-)
AKR/J	MGP_AKRJ_G0032011	protein coding gene	Chr7:36855056-37167381 (-)
BALB/cJ	MGP_BALBcJ_G0032085	protein coding gene	Chr7:36265281-36570149 (-)
C3H/HeJ	MGP_C3HHeJ_G0031802	protein coding gene	Chr7:37735561-38050226 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032562	protein coding gene	Chr7:38799452-39122944 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029595	protein coding gene	Chr7:36674463-36976110 (-)
CAST/EiJ	MGP_CASTEiJ_G0031137	protein coding gene	Chr7:28961052-29294727 (-)
CBA/J	MGP_CBAJ_G0031770	protein coding gene	Chr7:39995295-40343040 (-)
DBA/2J	MGP_DBA2J_G0031922	protein coding gene	Chr7:35797664-36100586 (-)
FVB/NJ	MGP_FVBNJ_G0031875	protein coding gene	Chr7:35718362-36021207 (-)
LP/J	MGP_LPJ_G0031999	protein coding gene	Chr7:37327492-37647404 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031915	protein coding gene	Chr7:38855427-39172980 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032577	protein coding gene	Chr7:36443170-36765088 (-)
PWK/PhJ	MGP_PWKPhJ_G0030859	protein coding gene	Chr7:29174840-29481524 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030694	protein coding gene	Chr7:25986941-26313639 (-)
WSB/EiJ	MGP_WSBEiJ_G0031247	protein coding gene	Chr7:36967764-37282836 (-)

Human Ortholog

ZNF536, zinc finger protein 536

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF536, zinc finger protein 536
Links

HGNC:29025

NCBI Gene ID: 9745

neXtProt AC: NX_O15090

UniProt: O15090
Chr Location

19q12; chr19:30224891-30713586 (+) GRCh38

MGI Vertebrate Homology

Zfp536 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZNF536
Gene Tree

Zfp536

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Gene trapped

3
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1167
Tissues

182
cDNA Data

14
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN znf536

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All Sequences

113
RefSeq

54
UniProt

7
CCDS

CCDS21156.1

Ensembl

ENSMUSG00000043456 (Evidence)
NCBI Gene

243937

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043456	Ensembl Gene Model \| MGI Sequence Detail	455618	C57BL/6J	± kb
transcript	ENSMUST00000175941	Ensembl \| MGI Sequence Detail	4423	Not Applicable
polypeptide	ENSMUSP00000134778	Ensembl \| MGI Sequence Detail	1302	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000017962 zinc finger protein 536

(term hierarchy)
InterPro Domains

IPR051967 Krueppel C2H2-type Zinc-Finger Domain-Containing Protein

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

Q8K083 1 site, 1 O-linked glycan (1 site)

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All nucleic 18

cDNA 14

Primer pair 2

Other 2

Microarray probesets 2

Summaries

All 43

Developmental Gene Expression 12

Gene Ontology 5

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zfp536:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr72082	Chr7:37473425-37473432 (-)	-363 bp
Tssr72081	Chr7:37473408-37473415 (-)	-346 bp
Tssr72080	Chr7:37472980-37473017 (-)	67 bp
Tssr72079	Chr7:37472950-37472972 (-)	105 bp
Tssr72078	Chr7:37472293-37472316 (-)	761 bp
Tssr72077	Chr7:37472158-37472199 (-)	887 bp
Tssr72076	Chr7:37470182-37470221 (-)	2,864 bp
Tssr72075	Chr7:37469742-37469766 (-)	3,312 bp
Tssr72074	Chr7:37469169-37469186 (-)	3,888 bp
Tssr72073	Chr7:37469151-37469162 (-)	3,909 bp
Tssr72072	Chr7:37469090-37469102 (-)	3,970 bp
Tssr72071	Chr7:37468842-37468846 (-)	4,222 bp
Tssr72070	Chr7:37290572-37290575 (-)	182,492 bp
Tssr72069	Chr7:37263077-37263081 (-)	209,987 bp
Tssr72068	Chr7:37178571-37178585 (-)	294,488 bp
Tssr72067	Chr7:37122473-37122477 (-)	350,591 bp
Tssr72065	Chr7:37019466-37019471 (-)	453,597 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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