Trmt44 MGI Mouse Gene Detail - MGI:1926140

Symbol

Trmt44
Name

tRNA methyltransferase 44
Synonyms

2310079F23Rik

Feature Type

protein coding gene
IDs

MGI:1926140
NCBI Gene: 78890
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr5:35713547-35732414 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 18.25 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

622 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926140	protein coding gene	Chr5:35713547-35732424 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029480	protein coding gene	Chr5:33844136-33861791 (-)
A/J	MGP_AJ_G0029447	protein coding gene	Chr5:32738287-32755876 (-)
AKR/J	MGP_AKRJ_G0029396	protein coding gene	Chr5:33995139-34012810 (-)
BALB/cJ	MGP_BALBcJ_G0029457	protein coding gene	Chr5:33257735-33275581 (-)
C3H/HeJ	MGP_C3HHeJ_G0029179	protein coding gene	Chr5:34012779-34030274 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029911	protein coding gene	Chr5:35756364-35774706 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027148	protein coding gene	Chr5:30502310-30519687 (-)
CAST/EiJ	MGP_CASTEiJ_G0028588	protein coding gene	Chr5:33107237-33125183 (-)
CBA/J	MGP_CBAJ_G0029147	protein coding gene	Chr5:36595607-36613230 (-)
DBA/2J	MGP_DBA2J_G0029295	protein coding gene	Chr5:32888693-32906362 (-)
FVB/NJ	MGP_FVBNJ_G0029254	protein coding gene	Chr5:32348197-32369740 (-)
LP/J	MGP_LPJ_G0029380	protein coding gene	Chr5:34279294-34296949 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029284	protein coding gene	Chr5:37399335-37417036 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029944	protein coding gene	Chr5:33498833-33516424 (-)
PWK/PhJ	MGP_PWKPhJ_G0028313	protein coding gene	Chr5:32050360-32068398 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028144	protein coding gene	Chr5:32960354-32979987 (-)
WSB/EiJ	MGP_WSBEiJ_G0028669	protein coding gene	Chr5:33560752-33579309 (-)

Human Ortholog

TRMT44, tRNA methyltransferase 44 homolog

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRMT44, tRNA methyltransferase 44 homolog
Synonyms

C4orf23, METTL19, TRM44
Links

HGNC:26653

NCBI Gene ID: 152992

neXtProt AC: NX_Q8IYL2

UniProt: Q8IYL2
Chr Location

4p16.1; chr4:8436140-8516950 (+) GRCh38

MGI Vertebrate Homology

Trmt44 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRMT44
Gene Tree

Trmt44

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

2
Radiation induced

4
Spontaneous

1
Targeted

2
Genomic Mutations

8 involving Trmt44
Incidental Mutations

APF
Find Mice (IMSR)

28 strains or lines available

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

24

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trmt44

ZFIN trmt44

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All Sequences

43
RefSeq

6
UniProt

4
CCDS

CCDS19230.1

Ensembl

ENSMUSG00000029097 (Evidence)
NCBI Gene

78890

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029097	Ensembl Gene Model \| MGI Sequence Detail	18868	C57BL/6J	± kb
transcript	ENSMUST00000030980	Ensembl \| MGI Sequence Detail	3790	Not Applicable
polypeptide	ENSMUSP00000030980	Ensembl \| MGI Sequence Detail	713	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000031666 probable tRNA (uracil-O(2)-)-methyltransferase

(term hierarchy)
EC

2.1.1.211
InterPro Domains

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

IPR011671 tRNA (uracil-O(2)-)-methyltransferase

IPR000571 Zinc finger, CCCH-type

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All nucleic 24

cDNA 24

Microarray probesets 2

Summaries

All 53

Diseases 1

Gene Ontology 5

Phenotypes 29
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Trmt44:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr50696	Chr5:35732390-35732427 (-)	5 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24