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Mdn1 Gene Detail
Summary
  • Symbol
    Mdn1
  • Name
    midasin AAA ATPase 1
  • Synonyms
    4833432B22Rik, D4Abb1e, LOC213784
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926159
    NCBI Gene: 100019
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:32657119-32775217 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 14.30 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2686 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926159
 protein coding gene Chr4:32656867-32775217 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028112
 protein coding gene Chr4:30125973-30250886 (+)
A/J MGP_AJ_G0028070
 protein coding gene Chr4:29062377-29180567 (+)
AKR/J MGP_AKRJ_G0028034
 protein coding gene Chr4:29813042-29934813 (+)
BALB/cJ MGP_BALBcJ_G0028081
 protein coding gene Chr4:29314845-29433920 (+)
C3H/HeJ MGP_C3HHeJ_G0027811
 protein coding gene Chr4:30099135-30221452 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028523
 protein coding gene Chr4:31304177-31430101 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025865
 protein coding gene Chr4:27123666-27244986 (+)
CAST/EiJ MGP_CASTEiJ_G0027265
 protein coding gene Chr4:29873015-29996319 (+)
CBA/J MGP_CBAJ_G0027783
 protein coding gene Chr4:32304962-32441562 (+)
DBA/2J MGP_DBA2J_G0027927
 protein coding gene Chr4:29067977-29186745 (+)
FVB/NJ MGP_FVBNJ_G0027892
 protein coding gene Chr4:28489131-28607218 (+)
LP/J MGP_LPJ_G0028035
 protein coding gene Chr4:30214024-30338010 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027925
 protein coding gene Chr4:34912301-35033091 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028582
 protein coding gene Chr4:29806037-29930919 (+)
PWK/PhJ MGP_PWKPhJ_G0026985
 protein coding gene Chr4:29031820-29154072 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026813
 protein coding gene Chr4:29695119-29817669 (+)
WSB/EiJ MGP_WSBEiJ_G0027342
 protein coding gene Chr4:29827694-29947153 (+)



Homology
more
  • Human Ortholog
    MDN1, midasin AAA ATPase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MDN1, midasin AAA ATPase 1
  • Synonyms
    Rea1
  • Links
    NCBI Gene ID: 23195
    neXtProt AC: NX_Q9NU22
    UniProt: Q9NU22

  • Chr Location
    6q15; chr6:89642498-89819794 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    125
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058006 Ensembl Gene Model | MGI Sequence Detail 118099 C57BL/6J ±  kb
transcript ENSMUST00000071642 Ensembl | MGI Sequence Detail 17970 Not Applicable  
polypeptide ENSMUSP00000071569 Ensembl | MGI Sequence Detail 5589 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR011704 ATPase, dynein-related, AAA domain
    IPR029317 KRBA1 family repeat
    IPR012099 Midasin
    IPR041190 Midasin AAA lid domain 5
    IPR040848 Midasin, AAA lid domain 7
    IPR048617 Midasin, lid domain 4
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
  • GlyGen
    J3QMC5 4 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 127
    cDNA 126
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-33917, MGI:106225, MGI:2140177, MGI:2684981
References
more
  • Summaries
    All 41
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:34960 Chambers DM, et al., Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains. Genome Res. 1996 Aug;6(8):715-23
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory