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Dlst Gene Detail
Summary
  • Symbol
    Dlst
  • Name
    dihydrolipoamide S-succinyltransferase
  • Synonyms
    1600017E01Rik, 4632413C10Rik, 4930529O08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926170
    NCBI Gene: 78920
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:85157597-85180865 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 39.55 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    513 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926170
 protein coding gene Chr12:85157597-85181619 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019952
 protein coding gene Chr12:85867083-85893064 (+)
A/J MGP_AJ_G0019909
 protein coding gene Chr12:82614184-82640370 (+)
AKR/J MGP_AKRJ_G0019885
 protein coding gene Chr12:84838771-84865301 (+)
BALB/cJ MGP_BALBcJ_G0019889
 protein coding gene Chr12:82947703-82974774 (+)
C3H/HeJ MGP_C3HHeJ_G0019695
 protein coding gene Chr12:85319106-85343106 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020340
 protein coding gene Chr12:88340968-88366782 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017958
 protein coding gene Chr12:79500068-79522838 (+)
CAST/EiJ MGP_CASTEiJ_G0019244
 protein coding gene Chr12:80291371-80316752 (+)
CBA/J MGP_CBAJ_G0019666
 protein coding gene Chr12:91736387-91765740 (+)
DBA/2J MGP_DBA2J_G0019781
 protein coding gene Chr12:82130104-82153230 (+)
FVB/NJ MGP_FVBNJ_G0019767
 protein coding gene Chr12:81090619-81114445 (+)
LP/J MGP_LPJ_G0019853
 protein coding gene Chr12:85744429-85769308 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019806
 protein coding gene Chr12:94611390-94635856 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020374
 protein coding gene Chr12:84449282-84475020 (+)
PWK/PhJ MGP_PWKPhJ_G0019008
 protein coding gene Chr12:76621147-76644869 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018803
 protein coding gene Chr12:78930440-78957141 (+)
WSB/EiJ MGP_WSBEiJ_G0019296
 protein coding gene Chr12:85170537-85193454 (+)



Homology
more
  • Human Ortholog
    DLST, dihydrolipoamide S-succinyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLST, dihydrolipoamide S-succinyltransferase
  • Synonyms
    DLTS, KGD2, PGL7, PPGL7
  • Links
    NCBI Gene ID: 1743
    neXtProt AC: NX_P36957
    UniProt: P36957

  • Chr Location
    14q24.3; chr14:74881891-74903743 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human DLST associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a gene trap allele exhibit an accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    883
  • Tissues
    145
  • cDNA Data
    266
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 78920 NCBI Gene Model | MGI Sequence Detail 23269 C57BL/6J ±  kb
transcript NM_030225 RefSeq | MGI Sequence Detail 2767 C57BL/6  
polypeptide Q9D2G2 UniProt | EBI | MGI Sequence Detail 454 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006526 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
    (term hierarchy)
  • EC
    2.3.1.61
  • InterPro Domains
    IPR050537 2-oxoacid dehydrogenase
    IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
    IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
    IPR000089 Biotin/lipoyl attachment
    IPR023213 Chloramphenicol acetyltransferase-like domain superfamily
    IPR006255 Dihydrolipoamide succinyltransferase
    IPR011053 Single hybrid motif
  • GlyGen
    Q9D2G2 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 267
    cDNA 266
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:1921476, MGI:2443879
References
more
  • Summaries
    All 58
    Developmental Gene Expression 8
    Gene Ontology 11
    Phenotypes 16
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:346910 Ayyangar U, et al., Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin. EMBO J. 2024 Apr;43(7):1113-1134
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory