Stap1 MGI Mouse Gene Detail - MGI:1926193 - signal transducing adaptor family member 1

Symbol

Stap1
Name

signal transducing adaptor family member 1
Synonyms

Brdg1, STAP-1

Feature Type

protein coding gene
IDs

MGI:1926193
NCBI Gene: 56792
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr5:86219446-86251859 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 43.56 cM, cytoband E1
Mapping Data

5 experiments

SNPs within 2kb

806 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926193	protein coding gene	Chr5:86219446-86253984 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029664	protein coding gene	Chr5:86897908-86935331 (+)
A/J	MGP_AJ_G0029632	protein coding gene	Chr5:83343215-83376592 (+)
AKR/J	MGP_AKRJ_G0029580	protein coding gene	Chr5:86110185-86143951 (+)
BALB/cJ	MGP_BALBcJ_G0029641	protein coding gene	Chr5:84251743-84284853 (+)
C3H/HeJ	MGP_C3HHeJ_G0029364	protein coding gene	Chr5:86601320-86635627 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030095	protein coding gene	Chr5:90480667-90519320 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027337	protein coding gene	Chr5:79209922-79246137 (+)
CAST/EiJ	MGP_CASTEiJ_G0028772	protein coding gene	Chr5:85854885-85894328 (+)
CBA/J	MGP_CBAJ_G0029333	protein coding gene	Chr5:93377076-93419162 (+)
DBA/2J	MGP_DBA2J_G0029478	protein coding gene	Chr5:83518961-83551275 (+)
FVB/NJ	MGP_FVBNJ_G0029439	protein coding gene	Chr5:82477247-82510869 (+)
LP/J	MGP_LPJ_G0029565	protein coding gene	Chr5:87306243-87338963 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029467	protein coding gene	Chr5:98184884-98231365 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030128	protein coding gene	Chr5:85695590-85733773 (+)
PWK/PhJ	MGP_PWKPhJ_G0028496	protein coding gene	Chr5:82503350-82537162 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028330	protein coding gene	Chr5:85050051-85081850 (+)
WSB/EiJ	MGP_WSBEiJ_G0028853	protein coding gene	Chr5:86035906-86070428 (+)

Human Ortholog

STAP1, signal transducing adaptor family member 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STAP1, signal transducing adaptor family member 1
Synonyms

BRDG1, STAP-1
Links

HGNC:24133

NCBI Gene ID: 26228

neXtProt AC: NX_Q9ULZ2

UniProt: Q9ULZ2
Chr Location

4q13.2; chr4:67558727-67607337 (+) GRCh38

MGI Vertebrate Homology

Stap1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: STAP1
Gene Tree

Stap1

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

4 involving Stap1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show no overt phenotype with no alterations in plasma lipid levels.

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All GO Annotations

42
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

49
RefSeq

8
UniProt

3
CCDS

CCDS19377.1, CCDS80312.1

Ensembl

ENSMUSG00000029254 (Evidence)
NCBI Gene

56792

			Length	Strain/Species	Flank
genomic	56792	NCBI Gene Model \| MGI Sequence Detail	32414	C57BL/6J	± kb
transcript	NM_019992	RefSeq \| MGI Sequence Detail	1225	C57BL/6
polypeptide	Q9JM90	UniProt \| EBI \| MGI Sequence Detail	297	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015713 signal-transducing adaptor protein 1

(term hierarchy)
InterPro Domains

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR039111 Signal-transducing adaptor protein STAP1/STAP2

IPR035877 STAP1, SH2 domain

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All nucleic 13

cDNA 13

Microarray probesets 3

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MGI:2140935

Summaries

All 45

Gene Ontology 9

Phenotypes 14
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Stap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46826	Chr5:86219404-86219421 (+)	-33 bp
Tssr46827	Chr5:86219426-86219445 (+)	-10 bp
Tssr46828	Chr5:86219475-86219487 (+)	35 bp
Tssr46829	Chr5:86219593-86219615 (+)	158 bp
Tssr46830	Chr5:86229030-86229071 (+)	9,605 bp
Tssr46831	Chr5:86231135-86231141 (+)	11,692 bp
Tssr46832	Chr5:86233674-86233683 (+)	14,233 bp
Tssr46833	Chr5:86234047-86234078 (+)	14,617 bp
Tssr46834	Chr5:86234124-86234140 (+)	14,686 bp
Tssr46835	Chr5:86237224-86237227 (+)	17,780 bp
Tssr46836	Chr5:86238811-86238825 (+)	19,372 bp
Tssr46837	Chr5:86239175-86239215 (+)	19,749 bp
Tssr46838	Chr5:86240069-86240075 (+)	20,626 bp
Tssr46839	Chr5:86241088-86241099 (+)	21,648 bp
Tssr46840	Chr5:86241100-86241117 (+)	21,663 bp
Tssr46841	Chr5:86241122-86241138 (+)	21,684 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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