Ylpm1 MGI Mouse Gene Detail - MGI:1926195

Symbol

Ylpm1
Name

YLP motif containing 1
Synonyms

A930013E17Rik, ZAP, Zap3

Feature Type

protein coding gene
IDs

MGI:1926195
NCBI Gene: 56531
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr12:85043095-85117289 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.50 cM, cytoband D3
Mapping Data

3 experiments

SNPs within 2kb

1522 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926195	protein coding gene	Chr12:85042977-85130501 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019950	protein coding gene	Chr12:85751032-85825869 (+)
A/J	MGP_AJ_G0019907	protein coding gene	Chr12:82498756-82573860 (+)
AKR/J	MGP_AKRJ_G0019883	protein coding gene	Chr12:84724293-84798453 (+)
BALB/cJ	MGP_BALBcJ_G0019887	protein coding gene	Chr12:82832896-82906615 (+)
C3H/HeJ	MGP_C3HHeJ_G0019693	protein coding gene	Chr12:85202912-85277841 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020338	protein coding gene	Chr12:88216346-88297151 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017956	protein coding gene	Chr12:79381840-79458373 (+)
CAST/EiJ	MGP_CASTEiJ_G0019242	protein coding gene	Chr12:80168040-80246373 (+)
CBA/J	MGP_CBAJ_G0019664	protein coding gene	Chr12:91620406-91695592 (+)
DBA/2J	MGP_DBA2J_G0019779	protein coding gene	Chr12:82015174-82088986 (+)
FVB/NJ	MGP_FVBNJ_G0019765	protein coding gene	Chr12:80975823-81049901 (+)
LP/J	MGP_LPJ_G0019851	protein coding gene	Chr12:85620989-85701217 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019804	protein coding gene	Chr12:94492328-94570132 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020372	protein coding gene	Chr12:84331247-84405022 (+)
PWK/PhJ	MGP_PWKPhJ_G0019006	protein coding gene	Chr12:76505058-76580042 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018801	protein coding gene	Chr12:78805096-78892034 (+)
WSB/EiJ	MGP_WSBEiJ_G0019294	protein coding gene	Chr12:85051109-85128664 (+)

Human Ortholog

YLPM1, YLP motif containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

YLPM1, YLP motif containing 1
Synonyms

C14orf170, PPP1R169, ZAP113, ZAP3
Links

HGNC:17798

NCBI Gene ID: 56252

neXtProt AC: NX_P49750

UniProt: P49750
Chr Location

14q24.3; chr14:74763316-74859435 (+) GRCh38

MGI Vertebrate Homology

Ylpm1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: YLPM1
Gene Tree

Ylpm1

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
1 images
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

16
Targeted

3
Genomic Mutations

1 involving Ylpm1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

95 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis.

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

772
Tissues

54
cDNA Data

111
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ylpm1

ZFIN ylpm1

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All Sequences

68
RefSeq

7
UniProt

7
CCDS

CCDS49114.1, CCDS88371.1

Ensembl

ENSMUSG00000021244 (Evidence)
NCBI Gene

56531

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021244	Ensembl Gene Model \| MGI Sequence Detail	74195	C57BL/6J	± kb
transcript	ENSMUST00000021670	Ensembl \| MGI Sequence Detail	7003	Not Applicable
polypeptide	ENSMUSP00000021670	Ensembl \| MGI Sequence Detail	2139	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000032170 YLP motif-containing protein 1

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR026314 YLP motif-containing protein 1
GlyGen

Q9R0I7 6 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (3 sites)

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All nucleic 112

cDNA 111

Primer pair 1

Microarray probesets 4

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MGI:2144901, MGI:2444150

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 13
Earliest

J:64959 Misawa K, et al., A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3062-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ylpm1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114368	Chr12:85043083-85043193 (+)	43 bp
Tssr114369	Chr12:85043210-85043215 (+)	118 bp
Tssr114370	Chr12:85043243-85043254 (+)	154 bp
Tssr114371	Chr12:85043261-85043270 (+)	171 bp
Tssr114372	Chr12:85043789-85043800 (+)	700 bp
Tssr114373	Chr12:85059795-85059835 (+)	16,720 bp
Tssr114374	Chr12:85076727-85076730 (+)	33,634 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24