Irgm2 MGI Mouse Gene Detail - MGI:1926262 - immunity-related GTPase family M member 2

Symbol

Irgm2
Name

immunity-related GTPase family M member 2
Synonyms

Gtpi, Iigp2

Feature Type

protein coding gene
IDs

MGI:1926262
NCBI Gene: 54396
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:58105803-58113609 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 36.07 cM
Mapping Data

1 experiment

SNPs within 2kb

119 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926262	protein coding gene	Chr11:58090444-58113609 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018346	protein coding gene	Chr11:57879087-57906842 (+)
A/J	MGP_AJ_G0018316	protein coding gene	Chr11:55668893-55710011 (+)
AKR/J	MGP_AKRJ_G0018285	protein coding gene	Chr11:57513956-57541668 (+)
BALB/cJ	MGP_BALBcJ_G0018287	protein coding gene	Chr11:56026748-56050655 (+)
C3H/HeJ	MGP_C3HHeJ_G0018098	protein coding gene	Chr11:57452052-57476352 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018738	protein coding gene	Chr11:59667295-59689101 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016388	protein coding gene	Chr11:53053423-53060365 (+)
CAST/EiJ	MGP_CASTEiJ_G0017663	protein coding gene	Chr11:57562395-57570165 (+)
CBA/J	MGP_CBAJ_G0018073	protein coding gene	Chr11:62411578-62441414 (+)
DBA/2J	MGP_DBA2J_G0018182	protein coding gene	Chr11:55350426-55358737 (+)
FVB/NJ	MGP_FVBNJ_G0018173	protein coding gene	Chr11:55047826-55051143 (+)
LP/J	MGP_LPJ_G0018257	protein coding gene	Chr11:58412427-58438531 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018199	protein coding gene	Chr11:63523934-63555179 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018781	protein coding gene	Chr11:57557852-57584404 (+)
PWK/PhJ	MGP_PWKPhJ_G0017435	protein coding gene	Chr11:55955440-55964110 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017230	protein coding gene	Chr11:57454739-57462572 (+)
WSB/EiJ	MGP_WSBEiJ_G0017710	protein coding gene	Chr11:57187729-57216415 (+)

Human Ortholog

IRGM, immunity related GTPase M

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IRGM, immunity related GTPase M
Synonyms

IBD19, IFI1, IRGM1, LRG-47, LRG47
Links

HGNC:29597

NCBI Gene ID: 345611

neXtProt AC: NX_A1A4Y4

UniProt: A1A4Y4
Chr Location

5q33.1; chr5:150846521-150902402 (+) GRCh38

MGI Vertebrate Homology

Irgm2 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: IRGM
Gene Tree

Irgm2

Diseases

2 with human IRGM associations

				Human Disease	Mouse Models
				inflammatory bowel disease 19 IDs inflammatory bowel disease 19 DOID:0110890 MESH:C567372 OMIM:612278
				tuberculosis IDs tuberculosis DOID:399 DOID:10096 DOID:12688 DOID:12691 DOID:415 DOID:9901 DOID:9902 MESH:D014375 UMLS_CUI:C0041295

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

6
Targeted

2
Genomic Mutations

1 involving Irgm2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit impaired cell-autonomous Toxoplasma killing.

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All GO Annotations

63
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

61

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS48803.1

Ensembl

ENSMUSG00000069874 (Evidence)
NCBI Gene

54396

			Length	Strain/Species	Flank
genomic	54396	NCBI Gene Model \| MGI Sequence Detail	7807	C57BL/6J	± kb
transcript	NM_019440	RefSeq \| MGI Sequence Detail	3537	C57BL/6
polypeptide	A0A140LIF8	UniProt \| EBI \| MGI Sequence Detail	395	Not Applicable

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UniProt

2 Sequences
EC

3.6.5.-
InterPro Domains

IPR051515 Immunity-related GTPase

IPR007743 Immunity-related GTPases-like

IPR030385 IRG-type guanine nucleotide-binding (G) domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

A0A140LIF8 1 site, 1 N-linked glycan (1 site)

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All nucleic 61

cDNA 61

Microarray probesets 3

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MGI:2144195

Summaries

All 44

Gene Ontology 10

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Irgm2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101708	Chr11:58111005-58111016 (+)	5,208 bp
Tssr101709	Chr11:58111307-58111336 (+)	5,519 bp
Tssr101710	Chr11:58111342-58111354 (+)	5,545 bp
Tssr101711	Chr11:58111503-58111540 (+)	5,719 bp
Tssr101712	Chr11:58111557-58111581 (+)	5,766 bp
Tssr101713	Chr11:58111875-58111900 (+)	6,085 bp
Tssr101714	Chr11:58111924-58111941 (+)	6,130 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24