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Gbp3 Gene Detail
Summary
  • Symbol
    Gbp3
  • Name
    guanylate binding protein 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926263
    NCBI Gene: 55932
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:142265787-142278970 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 66.69 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    628 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926263
 protein coding gene Chr3:142265781-142278974 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027943
 protein coding gene Chr3:145749246-145762408 (+)
A/J MGP_AJ_G0027900
 protein coding gene Chr3:140590971-140604506 (+)
AKR/J MGP_AKRJ_G0027866
 protein coding gene Chr3:144301030-144314150 (+)
BALB/cJ MGP_BALBcJ_G0027912
 protein coding gene Chr3:140392987-140407199 (+)
C3H/HeJ MGP_C3HHeJ_G0027642
 protein coding gene Chr3:144652959-144666143 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028356
 protein coding gene Chr3:150826981-150840136 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025694
 protein coding gene Chr3:135826034-135837830 (+)
CAST/EiJ MGP_CASTEiJ_G0027097
 protein coding gene Chr3:144573898-144599454 (+)
CBA/J MGP_CBAJ_G0027619
 protein coding gene Chr3:156011797-156025025 (+)
DBA/2J MGP_DBA2J_G0027758
 protein coding gene Chr3:139720487-139733646 (+)
FVB/NJ MGP_FVBNJ_G0027725
 protein coding gene Chr3:137143968-137152810 (+)
LP/J MGP_LPJ_G0027868
 protein coding gene Chr3:147179433-147193141 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027757
 protein coding gene Chr3:164332469-164345707 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028414
 protein coding gene Chr3:143917417-143930537 (+)
PWK/PhJ MGP_PWKPhJ_G0026822
 protein coding gene Chr3:139533759-139547599 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026649
 protein coding gene Chr3:142042297-142055528 (+)
WSB/EiJ MGP_WSBEiJ_G0027177
 protein coding gene Chr3:144775510-144791275 (+)



Homology
more
  • Human Ortholog
    GBP4, guanylate binding protein 4
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GBP4, guanylate binding protein 4
  • Synonyms
    Mpa2
  • Links
    NCBI Gene ID: 115361
    neXtProt AC: NX_Q96PP9
    UniProt: Q96PP9

  • Chr Location
    1p22.2; chr1:89181144-89198942 (-)  GRCh38
  • Human Ortholog
    GBP7, guanylate binding protein 7
  • Synonyms
    GBP4L
  • Links
    NCBI Gene ID: 388646
    neXtProt AC: NX_Q8N8V2
    UniProt: Q8N8V2

  • Chr Location
    1p22.2; chr1:89131742-89176009 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    63
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028268 Ensembl Gene Model | MGI Sequence Detail 13184 C57BL/6J ±  kb
transcript ENSMUST00000106221 Ensembl | MGI Sequence Detail 2682 Not Applicable  
polypeptide ENSMUSP00000101828 Ensembl | MGI Sequence Detail 620 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • EC
    3.6.5.-
  • InterPro Domains
    IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain
    IPR003191 Guanylate-binding protein/Atlastin, C-terminal
    IPR037684 Guanylate-binding protein, C-terminal
    IPR036543 Guanylate-binding protein, C-terminal domain superfamily
    IPR015894 Guanylate-binding protein, N-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
  • GlyGen
    Q61107 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 63
    cDNA 63

    Microarray probesets 3
Other
Accession IDs
less
MGI:2139979
References
more
  • Summaries
    All 57
    Diseases 1
    Gene Ontology 10
    Phenotypes 31
  • Earliest
    J:48603 Han BH, et al., Cloning, expression, and characterization of a novel guanylate-binding protein, GBP3 in murine erythroid progenitor cells. Biochim Biophys Acta. 1998 May 19;1384(2):373-86
  • Latest
    J:350745 Marinho FV, et al., Guanylate-binding protein-5 is involved in inflammasome activation by bacterial DNA but only the cooperation of multiple GBPs accounts for control of Brucella abortus infection. Front Immunol. 2024;15:1341464
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory