Mrpl19 MGI Mouse Gene Detail - MGI:1926274 - mitochondrial ribosomal protein L19

Symbol

Mrpl19
Name

mitochondrial ribosomal protein L19
Synonyms

9030416F12Rik, D6Ertd157e, MRP-L15, RLX1, Rpml15

Feature Type

protein coding gene
IDs

MGI:1926274
NCBI Gene: 56284
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr6:81934832-81942939 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 35.81 cM
Mapping Data

3 experiments

SNPs within 2kb

409 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926274	protein coding gene	Chr6:81934807-81942939 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030902	protein coding gene	Chr6:82926511-82936395 (-)
A/J	MGP_AJ_G0030871	protein coding gene	Chr6:79735331-79743410 (-)
AKR/J	MGP_AKRJ_G0030799	protein coding gene	Chr6:82009487-82017596 (-)
BALB/cJ	MGP_BALBcJ_G0030881	protein coding gene	Chr6:79760621-79768970 (-)
C3H/HeJ	MGP_C3HHeJ_G0030829	protein coding gene	Chr6:102317725-102327937 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031341	protein coding gene	Chr6:85166747-85176781 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028527	protein coding gene	Chr6:78164866-78172917 (-)
CAST/EiJ	MGP_CASTEiJ_G0029990	protein coding gene	Chr6:82024773-82032724 (-)
CBA/J	MGP_CBAJ_G0030568	protein coding gene	Chr6:88555565-88565359 (-)
DBA/2J	MGP_DBA2J_G0030721	protein coding gene	Chr6:79035784-79044662 (-)
FVB/NJ	MGP_FVBNJ_G0030674	protein coding gene	Chr6:78291987-78300072 (-)
LP/J	MGP_LPJ_G0030800	protein coding gene	Chr6:82908797-82919014 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030710	protein coding gene	Chr6:92882728-92892384 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031365	protein coding gene	Chr6:81856872-81864787 (-)
PWK/PhJ	MGP_PWKPhJ_G0029705	protein coding gene	Chr6:77951774-77960241 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029533	protein coding gene	Chr6:80719933-80727943 (-)
WSB/EiJ	MGP_WSBEiJ_G0030071	protein coding gene	Chr6:82289186-82299175 (-)

Human Ortholog

MRPL19, mitochondrial ribosomal protein L19

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MRPL19, mitochondrial ribosomal protein L19
Synonyms

bL19m, L15mt, L19mt, MRP-L15, MRPL15, MRP-L19, RLX1, RPML15
Links

HGNC:14052

NCBI Gene ID: 9801

neXtProt AC: NX_P49406

UniProt: P49406
Chr Location

2p12; chr2:75646783-75690851 (+) GRCh38

MGI Vertebrate Homology

Mrpl19 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MRPL19
Gene Tree

Mrpl19

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Phenotype Summary

9 phenotype references

All Mutations and Alleles

8
Endonuclease-mediated

3
Gene trapped

2
Spontaneous

1
Targeted

2
Genomic Mutations

2 involving Mrpl19
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available

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All GO Annotations

15
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

13
cDNA Data

18
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mrpl19

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All Sequences

46
RefSeq

2
UniProt

3
CCDS

CCDS39523.1

Ensembl

ENSMUSG00000030045 (Evidence)
NCBI Gene

56284

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030045	Ensembl Gene Model \| MGI Sequence Detail	8108	C57BL/6J	± kb
transcript	ENSMUST00000032124	Ensembl \| MGI Sequence Detail	5000	Not Applicable
polypeptide	ENSMUSP00000032124	Ensembl \| MGI Sequence Detail	292	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010581 large ribosomal subunit protein bL19m

(term hierarchy)
InterPro Domains

IPR001857 Large ribosomal subunit protein bL19

IPR038657 Large ribosomal subunit protein bL19 superfamily

IPR008991 Translation protein SH3-like domain superfamily

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All nucleic 21

cDNA 19

Primer pair 2

Microarray probesets 5

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MGI:1098795, MGI:1915232

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 9
Earliest

J:64919 Graack HR, et al., Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle. Biochemistry. 1999 Dec 14;38(50):16569-77
Latest

J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)

TSS for Mrpl19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr61576	Chr6:81942906-81942943 (-)	14 bp
Tssr61575	Chr6:81942646-81942660 (-)	286 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24