Sult2b1 MGI Mouse Gene Detail - MGI:1926342 - sulfotransferase family, cytosolic, 2B, member 1

Symbol

Sult2b1
Name

sulfotransferase family, cytosolic, 2B, member 1
Synonyms

Gm5897, SULT2B

Feature Type

protein coding gene
IDs

MGI:1926342
NCBI Gene: 54200
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr7:45379405-45409096 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.47 cM
Mapping Data

3 experiments

SNPs within 2kb

1058 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926342	protein coding gene	Chr7:45379405-45434093 (-)
129S1/SvImJ	ENSMUSG00200026433	protein coding gene	Chr7:32982939-33036907 (-)
A/J	ENSMUSG00195043278	protein coding gene	Chr7:37010361-37064797 (-)
AKR/J	ENSMUSG00220008564	protein coding gene	Chr7:31308591-31363299 (-)
BALB/cJ	ENSMUSG00180034147	protein coding gene	Chr7:33885755-33940197 (-)
C3H/HeJ	ENSMUSG00175026821	protein coding gene	Chr7:34418859-34472840 (-)
C57BL/6NJ	ENSMUSG00215040025	protein coding gene	Chr7:33672281-33726972 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029743	protein coding gene	Chr7:47680369-47709625 (-)
CAST/EiJ	ENSTCUG00005044728	protein coding gene	Chr7:37416677-37471020 (-)
CBA/J	ENSMUSG00210041017	protein coding gene	Chr7:34783253-34837951 (-)
DBA/2J	ENSMUSG00185037062	protein coding gene	Chr7:38665671-38719636 (-)
FVB/NJ	ENSMUSG00205018681	protein coding gene	Chr7:34327833-34382543 (-)
JF1/MsJ	ENSUMUG00000039838	protein coding gene	Chr7:43145381-43199372 (-)
LP/J	ENSMUSG00230050026	protein coding gene	Chr7:44099994-44154349 (-)
NOD/ShiLtJ	ENSMUSG00190049154	protein coding gene	Chr7:34655514-34710230 (-)
NZO/HlLtJ	ENSMUSG00225012734	protein coding gene	Chr7:42297358-42353616 (-)
PWK/PhJ	ENSLUMG00010046558	protein coding gene	Chr7:33618489-33672807 (-)
SPRET/EiJ	ENSMSPG00010031259	protein coding gene	Chr7:33387921-33441410 (-)
WSB/EiJ	ENSIUOG00005023411	protein coding gene	Chr7:35203774-35258060 (-)

Human Ortholog

SULT2B1, sulfotransferase family 2B member 1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SULT2B1, sulfotransferase family 2B member 1
Synonyms

ARCI14, HSST2
Links

HGNC:11459

NCBI Gene ID: 6820

UniProt: O00204
Chr Location

19q13.33; chr19:48552172-48599427 (+) GRCh38

MGI Vertebrate Homology

Sult2b1 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: SULT2B1
Gene Tree

Sult2b1

Diseases

1 with human SULT2B1 associations

				Human Disease	Mouse Models
				autosomal recessive congenital ichthyosis 14 IDs autosomal recessive congenital ichthyosis 14 DOID:0080258 OMIM:617571

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

6
Gene trapped

8
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available

Mice homozygous for a knock-out allele lack cholesterol sulfate in the dermis but otherwise appear to have normal lipid metabolism.

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All GO Annotations

43
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

117
cDNA Data

10
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sult2b1

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All Sequences

62
RefSeq

13
UniProt

4
CCDS

CCDS21263.1, CCDS90241.1

Ensembl

ENSMUSG00000003271 (Evidence)
NCBI Gene

54200

			Length	Strain/Species	Flank
genomic	54200	NCBI Gene Model \| MGI Sequence Detail	29692	C57BL/6J	± kb
transcript	NM_001360784	RefSeq \| MGI Sequence Detail	1271	C57BL/6
polypeptide	O35400	UniProt \| EBI \| MGI Sequence Detail	338	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015824 sulfotransferase 2B1

(term hierarchy)
EC

2.8.2.-, 2.8.2.2
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR000863 Sulfotransferase domain

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All nucleic 12

cDNA 10

Primer pair 2

Microarray probesets 4

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MGI:2141922, MGI:2142299, MGI:3648578

Summaries

All 56

Developmental Gene Expression 3

Gene Ontology 12

Phenotypes 17
Earliest

J:48327 Sakakibara Y, et al., Molecular cloning, expression, and functional characterization of novel mouse sulfotransferases. Biochem Biophys Res Commun. 1998 Jun 29;247(3):681-6
Latest

J:375731 Morino K, et al., Sulfotransferase SULT2B1 contributes to the epithelial-immune microenvironment homeostasis in imiquimod-induced psoriatic dermatitis. Front Immunol. 2025;16:1632426

TSS for Sult2b1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr72471	Chr7:45408951-45408962 (-)	139 bp
Tssr72470	Chr7:45408921-45408935 (-)	168 bp
Tssr72469	Chr7:45391879-45391892 (-)	17,210 bp
Tssr72468	Chr7:45391770-45391791 (-)	17,315 bp
Tssr72467	Chr7:45391748-45391765 (-)	17,339 bp
Tssr72466	Chr7:45391705-45391741 (-)	17,373 bp
Tssr2255	Chr7:45381370-45381374 (-)	27,724 bp
Tssr72465	Chr7:45381001-45381017 (-)	28,087 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24