Tg(Msx2)1Rem
Transgene Detail

Summary

• Symbol: Tg(Msx2)1Rem
• Name: transgene insertion 1, Robert E Maxson
• MGI ID: MGI:1926388
• Synonyms: CMV-Msx2, CMVMsx2WT, Msx2Tg
• Transgene: Tg(Msx2)1Rem Location: unknown
• Alliance: Tg(Msx2)1Rem page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Msx2)1Rem expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Msx2 (MGI:97169)

• Overexpression of mouse Msx2 in mouse under the control of the cytomegalovirus (CMV) promoter. (J:26513)
• Inheritance: Not Specified

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1  Disease Model	Tg(Msx2)1Rem/0	involves: C57BL/6 * CBA/J

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
craniofacial	√
ectopic cranial bone	√
hearing/vestibular/ear	√
abnormal ear morphology	√
integument	√
abnormal coat/ hair morphology	√
focal hair loss	√
short hair	√
abnormal hair shaft morphology	√
abnormal hair follicle morphology	√
abnormal hair follicle bulb morphology	√
abnormal hair follicle matrix region morphology	√
disorganized matrix sheath cells	√
abnormal hair follicle inner root sheath morphology	√
disorganized inner root sheath cells	√
abnormal hair follicle orientation	√
disorganized outer root sheath cells	√
thin hair follicle outer root sheath	√
distorted hair follicle pattern	√
abnormal skin morphology	√
abnormal dermal layer morphology	√
dermis papillary layer hypercellularity	√
abnormal epidermal layer morphology	√
abnormal epidermis stratum basale morphology	√
hyperkeratosis	√
disorganized suprabasal layer	√
thick epidermis suprabasal layer	√
epidermal desquamation	√
thick epidermis	√
flaky skin	√
scaly skin	√
thick skin	√
skeleton	√
ectopic cranial bone	√
premature cranial suture closure	√
vision/eye	√
abnormal eye morphology	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg1
craniosynostosis IDs craniosynostosis       DOID:2340 ICD10CM:Q75.0 MESH:D003398 NCI:C84655 OMIM:182212 OMIM:600593 ORDO:1531 UMLS_CUI:C0010278 Close	√

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

7 founder mice produced; number of transgenic lines established was not specified nor distinguished in paper.

References

• Original: J:26513 Liu YH, et al., Premature suture closure and ectopic cranial bone in mice expressing Msx2 transgenes in the developing skull. Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6137-41
• All: 4 reference(s)